Anti-inflammatory effect of a novel millet gliadin peptide on mice with colitis

A novel peptide (VSAAAA) was obtained after the isolation, purification, and identification of millet gliadin. In order to explore the anti-inflammatory effect of peptide VSAAAA in vivo, the peptide VSAAAA was administered in the first three weeks, and ulcerative colitis was induced in mice with DSS...

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Bibliographic Details
Published in:Journal of functional foods 2023-12, Vol.111, p.105912, Article 105912
Main Authors: Chen, Zhenjia, Zhang, Yidan, Zhang, Xinyue, Li, Xinpeng, Ma, Jiangong, Jing, Xu, Wang, Xiaowen
Format: Article
Language:English
Subjects:
Anti-inflammation
anti-inflammatory activity
aqueous solutions
Bacteroides
blood serum
Colitis
colon
cytokines
Firmicutes
gliadin
histopathology
intestinal microorganisms
Mice
Millet gliadin
millets
occludins
Peptide
ulcerative colitis
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Summary:A novel peptide (VSAAAA) was obtained after the isolation, purification, and identification of millet gliadin. In order to explore the anti-inflammatory effect of peptide VSAAAA in vivo, the peptide VSAAAA was administered in the first three weeks, and ulcerative colitis was induced in mice with DSS aqueous solution in the last week. Results showed that the disease activity index and histopathological changes in the colon were significantly reduced after VSAAAAA intervention. The expression levels of serum proinflammatory cytokines in mice were significantly reduced. In addition, VSAAAA gavage significantly alleviated decrease in the expression levels of the intestinal nexus proteins ZO-1 and occludin and increase in the expression levels of p65 and p-p65 proteins in the NF-κB signaling pathway. Moreover, the intestinal flora composition of colitis mice was regulated by decreasing the relative abundance of harmful bacteria (Firmicutes) and increasing the relative abundant of beneficial bacteria (Bacteroides).
ISSN:1756-4646
DOI:10.1016/j.jff.2023.105912