Cyclodepsipeptides and other O-containing heterocyclic metabolites from Beauveria felina EN-135, a marine-derived entomopathogenic fungus

Bioassay-guided fractionation of a culture extract of Beauveria felina EN-135, an entomopathogenic fungus isolated from a marine bryozoan, led to the isolation of a new cyclodepsipeptide, iso-isariin D (1); two new O-containing heterocyclic compounds that we have named felinones A and B (2 and 3); a...

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Bibliographic Details
Published in:Marine drugs 2014-05, Vol.12 (5), p.2816-2826
Main Authors: Du, Feng-Yu, Li, Xiao-Ming, Zhang, Peng, Li, Chun-Shun, Wang, Bin-Gui
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Artemia
Artemia salina
Bacteria - drug effects
Beauveria
Beauveria - chemistry
Beauveria felina
bioactivity
bryozoan
Depsipeptides - chemistry
Depsipeptides - isolation & purification
Depsipeptides - pharmacology
Drug Screening Assays, Antitumor
Fungi - drug effects
Heterocyclic Compounds - chemistry
Heterocyclic Compounds - isolation & purification
Heterocyclic Compounds - pharmacology
Marine
marine fungus
Microbial Sensitivity Tests
Models, Molecular
Molecular Conformation
secondary metabolites
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Summary:Bioassay-guided fractionation of a culture extract of Beauveria felina EN-135, an entomopathogenic fungus isolated from a marine bryozoan, led to the isolation of a new cyclodepsipeptide, iso-isariin D (1); two new O-containing heterocyclic compounds that we have named felinones A and B (2 and 3); and four known cyclodepsipeptides (4-7). The structures were elucidated via spectroscopic analysis, and the absolute configurations of 1 and 2 were determined using single-crystal X-ray diffraction and CD, respectively. All isolated compounds were evaluated for antimicrobial activity and brine-shrimp (Artemia salina) lethality.
ISSN:1660-3397
1660-3397
DOI:10.3390/md12052816