The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNT

This article strongly supports the Environmental Protection Agency proposal to make significant changes in their cancer risk assessment principles and practices by moving away from the use of the linear nonthreshold (LNT) dose–response as the default model. An alternate approach is proposed based on...

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Bibliographic Details
Published in:Dose-response 2018-07, Vol.16 (3), p.1559325818789840
Main Authors: Calabrese, Edward J., Hanekamp, Jaap C., Shamoun, Dima Yazji
Format: Article
Language:English
Subjects:
Cancer
Health risk assessment
Hormesis
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Summary:This article strongly supports the Environmental Protection Agency proposal to make significant changes in their cancer risk assessment principles and practices by moving away from the use of the linear nonthreshold (LNT) dose–response as the default model. An alternate approach is proposed based on model uncertainty which integrates the most scientifically supportable features of the threshold, hormesis, and LNT models to identify the doses that optimize population-based responses (ie, maximize health benefits/minimize health harm). This novel approach for cancer risk assessment represents a significant improvement to the current LNT default method from scientific and public health perspectives.
ISSN:1559-3258
1559-3258
DOI:10.1177/1559325818789840