Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer

Tumor cells stimulate local angiogenesis, resulting in their further multiplication and spread. Angiogenesis is a multifaceted process in which angiopoietins parti- cipate. Angiopoietin-1 (Ang-1) through its receptor Tie2 stimulates endothelial cell survival and the maintenance of the endothelial ba...

Full description

Saved in:
Bibliographic Details
Published in:Polish journal of pathology 2022-01, Vol.73 (1), p.6-13
Main Authors: Zalewska-Ziob, Marzena, Adamek, Brygida, Kasperczyk, Janusz, Dobija-Kubica, Katarzyna
Format: Article
Language:English
Subjects:
Angiogenesis
Angiopoietin
angiopoietin-1
Cell survival
Endothelial cells
Endothelium
Enzyme-linked immunosorbent assay
Enzymes
Extracellular matrix
five-year survival
Gene expression
Growth factors
Kinases
Lung cancer
Medical prognosis
non-small cell lung cancer
Non-small cell lung carcinoma
Patients
Small cell lung carcinoma
Smooth muscle
Thermal cycling
Thoracic surgery
Tumor cells
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c339t-fc69d9f15b2308c0fa24172fbd4e0f0c8e69fbe69bbfbea87e83ec55501e05943
cites
container_end_page 13
container_issue 1
container_start_page 6
container_title Polish journal of pathology
container_volume 73
creator Zalewska-Ziob, Marzena
Adamek, Brygida
Kasperczyk, Janusz
Dobija-Kubica, Katarzyna
description Tumor cells stimulate local angiogenesis, resulting in their further multiplication and spread. Angiogenesis is a multifaceted process in which angiopoietins parti- cipate. Angiopoietin-1 (Ang-1) through its receptor Tie2 stimulates endothelial cell survival and the maintenance of the endothelial barrier. These phenomena can support tumour growth by promoting angiogenesis. On the other hand, overproduction of Ang-1 triggers endothelium stability and can lead to angiogenesis inhibition. Because of the ambiguous role of Ang-1, we decided to determine its clinical significance in patients with resectable NSCLC. In a group of 47 patients, tumours and the adjacent non-cancerous tissues were assessed for ANG-1 mRNA expression (using Q-RT-PCR analysis) and Ang-1 concentration (by enzyme-linked immunosorbent assay) together with clinical parameters and the five-year survival rate. ANG-1 expression and Ang-1 concentration were higher in tumour-free tissue, showing no differences between histological types of NSCLC, clinical stage or grading and seemed not to determine the five-year survival. ANG-1 expression and Ang-1 concentration in tumour and tumour-free tissues in patients with NSCLC seem not to be useful as factors supporting either diagnostics or prognosis.
doi_str_mv 10.5114/pjp.2022.117176
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_005ed309397e4b4baba3d64b32097389</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_005ed309397e4b4baba3d64b32097389</doaj_id><sourcerecordid>2688082304</sourcerecordid><originalsourceid>FETCH-LOGICAL-c339t-fc69d9f15b2308c0fa24172fbd4e0f0c8e69fbe69bbfbea87e83ec55501e05943</originalsourceid><addsrcrecordid>eNpdUU1r3DAQFaWFLknOvQpyycUbfVmWjktoPiCkPbRnIcmjrRev5Ep2kv77yN3QQ3WYGR5Pj3nzEPpCybalVFxPh2nLCGNbSjvayQ9ow4gSjVZSf0QbyjhvtFTdZ3RRyoHUJwnrJN-g5-857WMq8-Dxsx0XwCngeTmmJeN5KKUCu6e7hmJ4nTKUMqSIbezxLu4r6FP0EOds5xUfIp7qVIGCX4b5F44pNuVox7HxMI54XOIee1u_5HP0KdixwMV7P0M_b7_-uLlvHr_dPdzsHhvPuZ6b4KXudaCtY5woT4JlgnYsuF4ACcQrkDq4WpyrzaoOFAffti2hQFot-Bl6OOn2yR7MlIejzX9MsoP5C6S8NzZX7yMYQlroOdFcdyCccNZZ3kvhOCO640pXrauT1pTT7wXKbI5DWY3ZCGkphklNhaRVp1Iv_6Me6kFjdVpZShFV7azLXZ9YPqdSMoR_C1Ji1lhNjdWssZpTrPwN3v-VoA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2688082304</pqid></control><display><type>article</type><title>Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer</title><source>Publicly Available Content (ProQuest)</source><source>Alma/SFX Local Collection</source><creator>Zalewska-Ziob, Marzena ; Adamek, Brygida ; Kasperczyk, Janusz ; Dobija-Kubica, Katarzyna</creator><creatorcontrib>Zalewska-Ziob, Marzena ; Adamek, Brygida ; Kasperczyk, Janusz ; Dobija-Kubica, Katarzyna</creatorcontrib><description>Tumor cells stimulate local angiogenesis, resulting in their further multiplication and spread. Angiogenesis is a multifaceted process in which angiopoietins parti- cipate. Angiopoietin-1 (Ang-1) through its receptor Tie2 stimulates endothelial cell survival and the maintenance of the endothelial barrier. These phenomena can support tumour growth by promoting angiogenesis. On the other hand, overproduction of Ang-1 triggers endothelium stability and can lead to angiogenesis inhibition. Because of the ambiguous role of Ang-1, we decided to determine its clinical significance in patients with resectable NSCLC. In a group of 47 patients, tumours and the adjacent non-cancerous tissues were assessed for ANG-1 mRNA expression (using Q-RT-PCR analysis) and Ang-1 concentration (by enzyme-linked immunosorbent assay) together with clinical parameters and the five-year survival rate. ANG-1 expression and Ang-1 concentration were higher in tumour-free tissue, showing no differences between histological types of NSCLC, clinical stage or grading and seemed not to determine the five-year survival. ANG-1 expression and Ang-1 concentration in tumour and tumour-free tissues in patients with NSCLC seem not to be useful as factors supporting either diagnostics or prognosis.</description><identifier>ISSN: 1233-9687</identifier><identifier>EISSN: 2084-9869</identifier><identifier>DOI: 10.5114/pjp.2022.117176</identifier><language>eng</language><publisher>Warsaw: Termedia Publishing House</publisher><subject>Angiogenesis ; Angiopoietin ; angiopoietin-1 ; Cell survival ; Endothelial cells ; Endothelium ; Enzyme-linked immunosorbent assay ; Enzymes ; Extracellular matrix ; five-year survival ; Gene expression ; Growth factors ; Kinases ; Lung cancer ; Medical prognosis ; non-small cell lung cancer ; Non-small cell lung carcinoma ; Patients ; Small cell lung carcinoma ; Smooth muscle ; Thermal cycling ; Thoracic surgery ; Tumor cells</subject><ispartof>Polish journal of pathology, 2022-01, Vol.73 (1), p.6-13</ispartof><rights>2022. This work is published under http://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-fc69d9f15b2308c0fa24172fbd4e0f0c8e69fbe69bbfbea87e83ec55501e05943</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2688082304/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2688082304?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590,75126</link.rule.ids></links><search><creatorcontrib>Zalewska-Ziob, Marzena</creatorcontrib><creatorcontrib>Adamek, Brygida</creatorcontrib><creatorcontrib>Kasperczyk, Janusz</creatorcontrib><creatorcontrib>Dobija-Kubica, Katarzyna</creatorcontrib><title>Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer</title><title>Polish journal of pathology</title><description>Tumor cells stimulate local angiogenesis, resulting in their further multiplication and spread. Angiogenesis is a multifaceted process in which angiopoietins parti- cipate. Angiopoietin-1 (Ang-1) through its receptor Tie2 stimulates endothelial cell survival and the maintenance of the endothelial barrier. These phenomena can support tumour growth by promoting angiogenesis. On the other hand, overproduction of Ang-1 triggers endothelium stability and can lead to angiogenesis inhibition. Because of the ambiguous role of Ang-1, we decided to determine its clinical significance in patients with resectable NSCLC. In a group of 47 patients, tumours and the adjacent non-cancerous tissues were assessed for ANG-1 mRNA expression (using Q-RT-PCR analysis) and Ang-1 concentration (by enzyme-linked immunosorbent assay) together with clinical parameters and the five-year survival rate. ANG-1 expression and Ang-1 concentration were higher in tumour-free tissue, showing no differences between histological types of NSCLC, clinical stage or grading and seemed not to determine the five-year survival. ANG-1 expression and Ang-1 concentration in tumour and tumour-free tissues in patients with NSCLC seem not to be useful as factors supporting either diagnostics or prognosis.</description><subject>Angiogenesis</subject><subject>Angiopoietin</subject><subject>angiopoietin-1</subject><subject>Cell survival</subject><subject>Endothelial cells</subject><subject>Endothelium</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Extracellular matrix</subject><subject>five-year survival</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>Kinases</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>non-small cell lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Patients</subject><subject>Small cell lung carcinoma</subject><subject>Smooth muscle</subject><subject>Thermal cycling</subject><subject>Thoracic surgery</subject><subject>Tumor cells</subject><issn>1233-9687</issn><issn>2084-9869</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdUU1r3DAQFaWFLknOvQpyycUbfVmWjktoPiCkPbRnIcmjrRev5Ep2kv77yN3QQ3WYGR5Pj3nzEPpCybalVFxPh2nLCGNbSjvayQ9ow4gSjVZSf0QbyjhvtFTdZ3RRyoHUJwnrJN-g5-857WMq8-Dxsx0XwCngeTmmJeN5KKUCu6e7hmJ4nTKUMqSIbezxLu4r6FP0EOds5xUfIp7qVIGCX4b5F44pNuVox7HxMI54XOIee1u_5HP0KdixwMV7P0M_b7_-uLlvHr_dPdzsHhvPuZ6b4KXudaCtY5woT4JlgnYsuF4ACcQrkDq4WpyrzaoOFAffti2hQFot-Bl6OOn2yR7MlIejzX9MsoP5C6S8NzZX7yMYQlroOdFcdyCccNZZ3kvhOCO640pXrauT1pTT7wXKbI5DWY3ZCGkphklNhaRVp1Iv_6Me6kFjdVpZShFV7azLXZ9YPqdSMoR_C1Ji1lhNjdWssZpTrPwN3v-VoA</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Zalewska-Ziob, Marzena</creator><creator>Adamek, Brygida</creator><creator>Kasperczyk, Janusz</creator><creator>Dobija-Kubica, Katarzyna</creator><general>Termedia Publishing House</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20220101</creationdate><title>Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer</title><author>Zalewska-Ziob, Marzena ; Adamek, Brygida ; Kasperczyk, Janusz ; Dobija-Kubica, Katarzyna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-fc69d9f15b2308c0fa24172fbd4e0f0c8e69fbe69bbfbea87e83ec55501e05943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiogenesis</topic><topic>Angiopoietin</topic><topic>angiopoietin-1</topic><topic>Cell survival</topic><topic>Endothelial cells</topic><topic>Endothelium</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Extracellular matrix</topic><topic>five-year survival</topic><topic>Gene expression</topic><topic>Growth factors</topic><topic>Kinases</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>non-small cell lung cancer</topic><topic>Non-small cell lung carcinoma</topic><topic>Patients</topic><topic>Small cell lung carcinoma</topic><topic>Smooth muscle</topic><topic>Thermal cycling</topic><topic>Thoracic surgery</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zalewska-Ziob, Marzena</creatorcontrib><creatorcontrib>Adamek, Brygida</creatorcontrib><creatorcontrib>Kasperczyk, Janusz</creatorcontrib><creatorcontrib>Dobija-Kubica, Katarzyna</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Biological Sciences</collection><collection>ProQuest Biological Science Journals</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Polish journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zalewska-Ziob, Marzena</au><au>Adamek, Brygida</au><au>Kasperczyk, Janusz</au><au>Dobija-Kubica, Katarzyna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer</atitle><jtitle>Polish journal of pathology</jtitle><date>2022-01-01</date><risdate>2022</risdate><volume>73</volume><issue>1</issue><spage>6</spage><epage>13</epage><pages>6-13</pages><issn>1233-9687</issn><eissn>2084-9869</eissn><abstract>Tumor cells stimulate local angiogenesis, resulting in their further multiplication and spread. Angiogenesis is a multifaceted process in which angiopoietins parti- cipate. Angiopoietin-1 (Ang-1) through its receptor Tie2 stimulates endothelial cell survival and the maintenance of the endothelial barrier. These phenomena can support tumour growth by promoting angiogenesis. On the other hand, overproduction of Ang-1 triggers endothelium stability and can lead to angiogenesis inhibition. Because of the ambiguous role of Ang-1, we decided to determine its clinical significance in patients with resectable NSCLC. In a group of 47 patients, tumours and the adjacent non-cancerous tissues were assessed for ANG-1 mRNA expression (using Q-RT-PCR analysis) and Ang-1 concentration (by enzyme-linked immunosorbent assay) together with clinical parameters and the five-year survival rate. ANG-1 expression and Ang-1 concentration were higher in tumour-free tissue, showing no differences between histological types of NSCLC, clinical stage or grading and seemed not to determine the five-year survival. ANG-1 expression and Ang-1 concentration in tumour and tumour-free tissues in patients with NSCLC seem not to be useful as factors supporting either diagnostics or prognosis.</abstract><cop>Warsaw</cop><pub>Termedia Publishing House</pub><doi>10.5114/pjp.2022.117176</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1233-9687
ispartof Polish journal of pathology, 2022-01, Vol.73 (1), p.6-13
issn 1233-9687
2084-9869
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_005ed309397e4b4baba3d64b32097389
source Publicly Available Content (ProQuest); Alma/SFX Local Collection
subjects Angiogenesis
Angiopoietin
angiopoietin-1
Cell survival
Endothelial cells
Endothelium
Enzyme-linked immunosorbent assay
Enzymes
Extracellular matrix
five-year survival
Gene expression
Growth factors
Kinases
Lung cancer
Medical prognosis
non-small cell lung cancer
Non-small cell lung carcinoma
Patients
Small cell lung carcinoma
Smooth muscle
Thermal cycling
Thoracic surgery
Tumor cells
title Prognostic value of tumour tissue ANG-1 expression and Ang-1 concentration in patients with non-small-cell lung cancer
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T14%3A24%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20value%20of%20tumour%20tissue%20ANG-1%20expression%20and%20Ang-1%20concentration%20in%20patients%20with%20non-small-cell%20lung%20cancer&rft.jtitle=Polish%20journal%20of%20pathology&rft.au=Zalewska-Ziob,%20Marzena&rft.date=2022-01-01&rft.volume=73&rft.issue=1&rft.spage=6&rft.epage=13&rft.pages=6-13&rft.issn=1233-9687&rft.eissn=2084-9869&rft_id=info:doi/10.5114/pjp.2022.117176&rft_dat=%3Cproquest_doaj_%3E2688082304%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c339t-fc69d9f15b2308c0fa24172fbd4e0f0c8e69fbe69bbfbea87e83ec55501e05943%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2688082304&rft_id=info:pmid/&rfr_iscdi=true