Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be...

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Bibliographic Details
Published in:Analytical cellular pathology (Amsterdam) 2019, Vol.2019 (2019), p.1-9
Main Authors: Wang, Lixin, Peng, Jiahuan, Xie, Xiaochen, Zuo, Huanhuan, Zhu, Rong
Format: Article
Language:English
Subjects:
Aged
Biomarkers - metabolism
Blood Platelets - pathology
Carboxypeptidase B - metabolism
Disease Progression
Electrocardiography
Female
Humans
Hypertension, Pulmonary - complications
Hypertension, Pulmonary - diagnostic imaging
Hypertension, Pulmonary - pathology
Inflammation - immunology
Inflammation - pathology
Lymphocytes - pathology
Male
Multivariate Analysis
Natriuretic Peptide, Brain - metabolism
Neutrophils - pathology
Peptide Fragments - metabolism
Predictive Value of Tests
Pulmonary Disease, Chronic Obstructive - complications
Pulmonary Disease, Chronic Obstructive - diagnostic imaging
Pulmonary Disease, Chronic Obstructive - pathology
ROC Curve
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Summary:Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to evaluate the clinical significance of these biomarkers to predict PH in patients with AECOPD. According to the diagnostic criterion for PH by Doppler echocardiography, the patients were stratified into two groups. The study group consisted of 101 patients complicated with PH, and the control group had 84 patients. The NLR, PLR, and SII values of the PH group were significantly higher than those of the AECOPD one (p
ISSN:2210-7177
2210-7185
DOI:10.1155/2019/5189165