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Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be...
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| Published in: | Analytical cellular pathology (Amsterdam) 2019, Vol.2019 (2019), p.1-9 |
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| creator | Wang, Lixin Peng, Jiahuan Xie, Xiaochen Zuo, Huanhuan Zhu, Rong |
| description | Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to evaluate the clinical significance of these biomarkers to predict PH in patients with AECOPD. According to the diagnostic criterion for PH by Doppler echocardiography, the patients were stratified into two groups. The study group consisted of 101 patients complicated with PH, and the control group had 84 patients. The NLR, PLR, and SII values of the PH group were significantly higher than those of the AECOPD one (p |
| doi_str_mv | 10.1155/2019/5189165 |
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This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to evaluate the clinical significance of these biomarkers to predict PH in patients with AECOPD. According to the diagnostic criterion for PH by Doppler echocardiography, the patients were stratified into two groups. The study group consisted of 101 patients complicated with PH, and the control group had 84 patients. The NLR, PLR, and SII values of the PH group were significantly higher than those of the AECOPD one (p<0.05). The blood biomarker levels were positively correlated with NT-proBNP levels, while they had no significant correlation with the estimated pulmonary arterial systolic pressure (PASP) other than PLR. NLR, PLR, and SII values were all associated with PH (p<0.05) in the univariate analysis, but not in the multivariate analysis. The AUC of NLR used for predicting PH was 0.701 and was higher than PLR and SII. Using 4.659 as the cut-off value of NLR, the sensitivity was 81.2%, and the specificity was 59.5%. In conclusion, these simple markers may be useful in the prediction of PH in patients with AECOPD.</description><identifier>ISSN: 2210-7177</identifier><identifier>EISSN: 2210-7185</identifier><identifier>DOI: 10.1155/2019/5189165</identifier><identifier>PMID: 31737467</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aged ; Biomarkers - metabolism ; Blood Platelets - pathology ; Carboxypeptidase B - metabolism ; Disease Progression ; Electrocardiography ; Female ; Humans ; Hypertension, Pulmonary - complications ; Hypertension, Pulmonary - diagnostic imaging ; Hypertension, Pulmonary - pathology ; Inflammation - immunology ; Inflammation - pathology ; Lymphocytes - pathology ; Male ; Multivariate Analysis ; Natriuretic Peptide, Brain - metabolism ; Neutrophils - pathology ; Peptide Fragments - metabolism ; Predictive Value of Tests ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - diagnostic imaging ; Pulmonary Disease, Chronic Obstructive - pathology ; ROC Curve</subject><ispartof>Analytical cellular pathology (Amsterdam), 2019, Vol.2019 (2019), p.1-9</ispartof><rights>Copyright © 2019 Huanhuan Zuo et al.</rights><rights>Copyright © 2019 Huanhuan Zuo et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-def1ee2dca9f0d996f6dce2f6231535eccfb238c3903ab1f924301ec7d61aeaa3</citedby><cites>FETCH-LOGICAL-c509t-def1ee2dca9f0d996f6dce2f6231535eccfb238c3903ab1f924301ec7d61aeaa3</cites><orcidid>0000-0001-5472-6104</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815641/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815641/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31737467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yun, Xin</contributor><creatorcontrib>Wang, Lixin</creatorcontrib><creatorcontrib>Peng, Jiahuan</creatorcontrib><creatorcontrib>Xie, Xiaochen</creatorcontrib><creatorcontrib>Zuo, Huanhuan</creatorcontrib><creatorcontrib>Zhu, Rong</creatorcontrib><title>Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease</title><title>Analytical cellular pathology (Amsterdam)</title><addtitle>Anal Cell Pathol (Amst)</addtitle><description>Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to evaluate the clinical significance of these biomarkers to predict PH in patients with AECOPD. According to the diagnostic criterion for PH by Doppler echocardiography, the patients were stratified into two groups. The study group consisted of 101 patients complicated with PH, and the control group had 84 patients. The NLR, PLR, and SII values of the PH group were significantly higher than those of the AECOPD one (p<0.05). The blood biomarker levels were positively correlated with NT-proBNP levels, while they had no significant correlation with the estimated pulmonary arterial systolic pressure (PASP) other than PLR. NLR, PLR, and SII values were all associated with PH (p<0.05) in the univariate analysis, but not in the multivariate analysis. The AUC of NLR used for predicting PH was 0.701 and was higher than PLR and SII. Using 4.659 as the cut-off value of NLR, the sensitivity was 81.2%, and the specificity was 59.5%. In conclusion, these simple markers may be useful in the prediction of PH in patients with AECOPD.</description><subject>Aged</subject><subject>Biomarkers - metabolism</subject><subject>Blood Platelets - pathology</subject><subject>Carboxypeptidase B - metabolism</subject><subject>Disease Progression</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - complications</subject><subject>Hypertension, Pulmonary - diagnostic imaging</subject><subject>Hypertension, Pulmonary - pathology</subject><subject>Inflammation - immunology</subject><subject>Inflammation - pathology</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Natriuretic Peptide, Brain - metabolism</subject><subject>Neutrophils - pathology</subject><subject>Peptide Fragments - metabolism</subject><subject>Predictive Value of Tests</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</subject><subject>Pulmonary Disease, Chronic Obstructive - pathology</subject><subject>ROC Curve</subject><issn>2210-7177</issn><issn>2210-7185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqNkk1v1DAQhiMEolXpjTPyEQmW-iNO4gtSuxS6UkV7AK7WxB53XZK42MnC_hD-L97usqU3fLE1fvTMjPQWxUtG3zEm5QmnTJ1I1ihWySfFIeeMzmrWyKf7d10fFMcp3dJ8hFKKyufFgWC1qMuqPix-X0e03ox-heQbdBOS4MjnsMKOLAbXQd_D6MMwO4OElpz50EP8jjERFyK5nro-DBDX5GJ9h3HEIWWW-IGMSySnZhqRnP8Cg7G9t2zc82UMgzfkqk1jnLaNHzwffMLc6UXxzEGX8Hh3HxVfP55_mV_MLq8-LeanlzMjqRpnFh1D5NaActQqVbnKGuSu4oJJIdEY13LRGKGogJY5xUtBGZraVgwQQBwVi63XBrjVd9Hn7dY6gNf3hRBvNMTRmw41pVVTNqVDqrDkClrLVKlcCWBt2TY8u95vXXdT22OeYxgjdI-kj38Gv9Q3YaWrhsmqZFnweieI4ceEadS9Twa7DgYMU9KbpSSvGqEy-naLmhhSiuj2bRjVm2DoTTD0LhgZf_XvaHv4bwwy8GYLLP1g4af_Tx1mBh080IzVjRTiD781zpA</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Wang, Lixin</creator><creator>Peng, Jiahuan</creator><creator>Xie, Xiaochen</creator><creator>Zuo, Huanhuan</creator><creator>Zhu, Rong</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5472-6104</orcidid></search><sort><creationdate>2019</creationdate><title>Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease</title><author>Wang, Lixin ; Peng, Jiahuan ; Xie, Xiaochen ; Zuo, Huanhuan ; Zhu, Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-def1ee2dca9f0d996f6dce2f6231535eccfb238c3903ab1f924301ec7d61aeaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Biomarkers - metabolism</topic><topic>Blood Platelets - pathology</topic><topic>Carboxypeptidase B - metabolism</topic><topic>Disease Progression</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - complications</topic><topic>Hypertension, Pulmonary - diagnostic imaging</topic><topic>Hypertension, Pulmonary - pathology</topic><topic>Inflammation - immunology</topic><topic>Inflammation - pathology</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Natriuretic Peptide, Brain - metabolism</topic><topic>Neutrophils - pathology</topic><topic>Peptide Fragments - metabolism</topic><topic>Predictive Value of Tests</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</topic><topic>Pulmonary Disease, Chronic Obstructive - pathology</topic><topic>ROC Curve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Lixin</creatorcontrib><creatorcontrib>Peng, Jiahuan</creatorcontrib><creatorcontrib>Xie, Xiaochen</creatorcontrib><creatorcontrib>Zuo, Huanhuan</creatorcontrib><creatorcontrib>Zhu, Rong</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Analytical cellular pathology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Lixin</au><au>Peng, Jiahuan</au><au>Xie, Xiaochen</au><au>Zuo, Huanhuan</au><au>Zhu, Rong</au><au>Yun, Xin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease</atitle><jtitle>Analytical cellular pathology (Amsterdam)</jtitle><addtitle>Anal Cell Pathol (Amst)</addtitle><date>2019</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2210-7177</issn><eissn>2210-7185</eissn><abstract>Recently, there has been an increasing interest in the potential clinical use of several inflammatory indexes, namely, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). This study aimed at assessing whether these markers could be early indicators of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total of 185 patients were enrolled in our retrospective study from January 2017 to January 2019. Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to evaluate the clinical significance of these biomarkers to predict PH in patients with AECOPD. According to the diagnostic criterion for PH by Doppler echocardiography, the patients were stratified into two groups. The study group consisted of 101 patients complicated with PH, and the control group had 84 patients. The NLR, PLR, and SII values of the PH group were significantly higher than those of the AECOPD one (p<0.05). The blood biomarker levels were positively correlated with NT-proBNP levels, while they had no significant correlation with the estimated pulmonary arterial systolic pressure (PASP) other than PLR. NLR, PLR, and SII values were all associated with PH (p<0.05) in the univariate analysis, but not in the multivariate analysis. The AUC of NLR used for predicting PH was 0.701 and was higher than PLR and SII. Using 4.659 as the cut-off value of NLR, the sensitivity was 81.2%, and the specificity was 59.5%. In conclusion, these simple markers may be useful in the prediction of PH in patients with AECOPD.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31737467</pmid><doi>10.1155/2019/5189165</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5472-6104</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biomarkers - metabolism Blood Platelets - pathology Carboxypeptidase B - metabolism Disease Progression Electrocardiography Female Humans Hypertension, Pulmonary - complications Hypertension, Pulmonary - diagnostic imaging Hypertension, Pulmonary - pathology Inflammation - immunology Inflammation - pathology Lymphocytes - pathology Male Multivariate Analysis Natriuretic Peptide, Brain - metabolism Neutrophils - pathology Peptide Fragments - metabolism Predictive Value of Tests Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - pathology ROC Curve |
| title | Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
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