Association of optic disc pallor and RNFL thickness with cerebral small vessel disease in the PREVENT‐Dementia study

INTRODUCTION We tested associations between two retinal measures (optic disc pallor, peripapillary retinal nerve fiber layer [pRNFL] thickness) and four magnetic resonance imaging markers of cerebral small vessel disease (SVD; lacunes, microbleeds, white matter hyperintensities, and enlarged perivas...

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Published in:Alzheimer's & dementia : diagnosis, assessment & disease monitoring assessment & disease monitoring, 2024-07, Vol.16 (3), p.e12633-n/a
Main Authors: Gibbon, Samuel, Low, Audrey, Hamid, Charlene, Reid‐Schachter, Megan, Muniz‐Terrera, Graciela, Ritchie, Craig W., Trucco, Emanuele, Dhillon, Baljean, O'Brien, John T., MacGillivray, Thomas J.
Format: Article
Language:English
Subjects:
Brain research
cerebral small vessel disease
Dementia
Disease
Family medical history
Magnetic resonance imaging
optic disc pallor
Quality control
retina
Software
Surgery
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Summary:INTRODUCTION We tested associations between two retinal measures (optic disc pallor, peripapillary retinal nerve fiber layer [pRNFL] thickness) and four magnetic resonance imaging markers of cerebral small vessel disease (SVD; lacunes, microbleeds, white matter hyperintensities, and enlarged perivascular spaces [ePVSs]). METHODS We used PallorMetrics to quantify optic disc pallor from fundus photographs, and pRNFL thickness from optical coherence tomography scans. Linear and logistic regression assessed relationships between retinal measures and SVD markers. Participants (N = 108, mean age 51.6) were from the PREVENT Dementia study. RESULTS Global optic disc pallor was linked to ePVSs in the basal ganglia in both left (β = 0.12, standard error [SE] = 0.05, P 
ISSN:2352-8729
2352-8729
DOI:10.1002/dad2.12633