Adding recombinant AAVs to the cancer therapeutics mix

Gene therapy is a powerful biological tool that is reshaping therapeutic landscapes for several diseases. Researchers are using both non-viral and viral-based gene therapy methods with success in the lab and the clinic. In the cancer biology field, gene therapies are expanding treatment options and...

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Bibliographic Details
Published in:Molecular therapy. Oncolytics 2022-12, Vol.27, p.73-88
Main Authors: Mulcrone, Patrick L., Herzog, Roland W., Xiao, Weidong
Format: Article
Language:English
Subjects:
AAV design
cancer
gene therapy
rAAV
Review
tissue tropism
tumor microenvironment
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Summary:Gene therapy is a powerful biological tool that is reshaping therapeutic landscapes for several diseases. Researchers are using both non-viral and viral-based gene therapy methods with success in the lab and the clinic. In the cancer biology field, gene therapies are expanding treatment options and the possibility of favorable outcomes for patients. While cellular immunotherapies and oncolytic virotherapies have paved the way in cancer treatments based on genetic engineering, recombinant adeno-associated virus (rAAV), a viral-based module, is also emerging as a potential cancer therapeutic through its malleability, specificity, and broad application to common as well as rare tumor types, tumor microenvironments, and metastatic disease. A wide range of AAV serotypes, promoters, and transgenes have been successful at reducing tumor growth and burden in preclinical studies, suggesting more groundbreaking advances using rAAVs in cancer are on the horizon. [Display omitted] Various gene therapies are effective in treating several diseases, including cancers. Along with brief explanations of the many gene therapies impacting cancer, W. Xiao and colleagues focus on recombinant adeno-associated viruses, a gene therapy with the potential to revolutionize cancer treatments due to their versatility, specificity, and minimal side effects.
ISSN:2372-7705
2372-7705
DOI:10.1016/j.omto.2022.09.009