Delayed Laboratory Response to COVID-19 Caused by Molecular Diagnostic Contamination

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) created an exceptional situation in which numerous laboratories in Europe simultaneously implemented SARS-CoV-2 diagnostics. These laboratories reported in February 2020 that commercial primer and probe batches for SARS-Co...

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Bibliographic Details
Published in:Emerging infectious diseases 2020-08, Vol.26 (8), p.1944-1946
Main Authors: Mögling, Ramona, Meijer, Adam, Berginc, Natasa, Bruisten, Sylvia, Charrel, Remi, Coutard, Bruno, Eckerle, Isabella, Enouf, Vincent, Hungnes, Olav, Korukluoglu, Gülay, Kossyvakis, Thanos, Mentis, Andreas, Molenkamp, Richard, Muradrasoli, Shaman, Papa, Anna, Pigny, Fiona, Thirion, Laurence, van der Werf, Sylvie, Reusken, Chantal
Format: Article
Language:English
Subjects:
Acids
Betacoronavirus - genetics
Betacoronavirus - pathogenicity
Clinical Laboratory Techniques - methods
Clinical Laboratory Techniques - standards
coronavirus disease
Coronavirus Envelope Proteins
Coronavirus Infections - diagnosis
Coronavirus Infections - epidemiology
Coronavirus Infections - virology
Coronaviruses
COVID-19
COVID-19 Testing
Delayed Diagnosis
delayed laboratory response
Delayed Laboratory Response to COVID-19 Caused by Molecular Diagnostic Contamination
Diagnosis
Diagnostic Tests, Routine
DNA Primers - analysis
DNA Primers - chemical synthesis
DNA Probes - analysis
DNA Probes - chemical synthesis
Europe - epidemiology
Health aspects
Humans
Laboratories
Laboratories - organization & administration
Laboratories - standards
Life Sciences
Pandemics
Pathology, Molecular
Pneumonia, Viral - diagnosis
Pneumonia, Viral - epidemiology
Pneumonia, Viral - virology
Reagent Kits, Diagnostic - standards
Reagent Kits, Diagnostic - supply & distribution
Research Letter
Reverse Transcriptase Polymerase Chain Reaction - standards
Reverse Transcriptase Polymerase Chain Reaction - statistics & numerical data
RNA-Dependent RNA Polymerase - genetics
SARS-CoV-2
Severe acute respiratory syndrome
severe acute respiratory syndrome coronavirus 2
Viral Envelope Proteins - genetics
viruses
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Description
Summary:The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) created an exceptional situation in which numerous laboratories in Europe simultaneously implemented SARS-CoV-2 diagnostics. These laboratories reported in February 2020 that commercial primer and probe batches for SARS-CoV-2 detection were contaminated with synthetic control material, causing delays of regional testing roll-out in various countries.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2608.201843