Correlating blood levels of 8-hydroxydeoxyguanosine to hOGG1 genotypes and the incidence of ischemic cardiomyopathy

Abstract We measured the serum levels of 8-hydroxydeoxyguanosine (8-OHdG) and investigated whether these levels correlate with incidence of ischemic cardiomyopathy (ICM), and whether these levels correlate with underlying oxidative stress in patients with ICM. Polymerase chain reaction-restriction f...

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Bibliographic Details
Published in:The Kaohsiung journal of medical sciences 2016-05, Vol.32 (5), p.241-247
Main Authors: Jin, Yu, Qiu, Chun-Guang, Zheng, Qiang-Sun, Ding, Shi-Fang, Jiang, Qi-Jun
Format: Article
Language:English
Subjects:
8-hydroxy guanine glycosylase
8-hydroxy-deoxyguanosine
Adult
Aged
C-Reactive Protein - metabolism
Cardiomyopathies - blood
Cardiomyopathies - enzymology
Cardiomyopathies - genetics
Case-Control Studies
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - blood
DNA Glycosylases - blood
DNA Glycosylases - genetics
Electrophoresis, Agar Gel
Female
Fibrinogen - metabolism
Gene Frequency - genetics
Genetic Predisposition to Disease
Humans
Incidence
Internal Medicine
Ischemic cardiomyopathy
Lipids - blood
Male
Middle Aged
Myocardial Ischemia - blood
Myocardial Ischemia - enzymology
Myocardial Ischemia - genetics
Oxidative stress
Polymorphism
Risk Factors
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Summary:Abstract We measured the serum levels of 8-hydroxydeoxyguanosine (8-OHdG) and investigated whether these levels correlate with incidence of ischemic cardiomyopathy (ICM), and whether these levels correlate with underlying oxidative stress in patients with ICM. Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to assess the prevalence of the Ser/Cys polymorphism in the human 8-oxoguanine glycosylase ( hOGG1 ) gene. We analyzed the samples from 246 ICM cases (the ICM group) and another 246 age- and sex-matched volunteers with normal coronary artery function (the control group). Levels of 8-OHdG in participants' blood samples were 6.7 ± 1.7 and 3.0 ± 0.8 in the ICM and control groups, respectively ( p  
ISSN:1607-551X
2410-8650
DOI:10.1016/j.kjms.2016.04.010