HBx Mediated Increase of DDX17 Contributes to HBV-Related Hepatocellular Carcinoma Tumorigenesis

HBV is strongly associated with HCC development and DEAD-box RNA helicase 17 (DDX17) is a very important member of the DEAD box family that plays key roles in HCC development by promoting cancer metastasis. However, the important role of DDX17 in the pathogenesis of HBV-related HCC remains unclear....

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Published in:Frontiers in immunology 2022-06, Vol.13, p.871558-871558
Main Authors: Dong, Mei-Ling, Wen, Xu, He, Xin, Ren, Ji-Hua, Yu, Hai-Bo, Qin, Yi-Ping, Yang, Zhen, Yang, Min-Li, Zhou, Chong-Yang, Zhang, Hui, Cheng, Sheng-Tao, Chen, Juan
Format: Article
Language:English
Subjects:
DDX17
HBx
HCC
Immunology
metastasis
ZWINT
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Summary:HBV is strongly associated with HCC development and DEAD-box RNA helicase 17 (DDX17) is a very important member of the DEAD box family that plays key roles in HCC development by promoting cancer metastasis. However, the important role of DDX17 in the pathogenesis of HBV-related HCC remains unclear. In this study, we investigated the role of DDX17 in the replication of HBV and the development of HBV-associated HCC. Based on data from the GEO database and HBV-infected cells, we found that DDX17 was upregulated by the HBV viral protein X (HBx). Mechanistically, increased DDX17 expression promoted HBV replication and transcription by upregulating ZWINT. Further study showed that DDX17 could promote HBx-mediated HCC metastasis. Finally, the promotive effect of DDX17 on HBV and HBV-related HCC was confirmed in vivo . In summary, the results revealed the novel role of DDX17 in the replication of HBV and the metastasis of HBV-associated HCC.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.871558