Hydrogel-Encapsulated Heterogenous Mesoporous Resin Catalyst for In Situ Anti-Cancer Agent Production under Biological Conditions

A heterogenous Palladium anchored Resorcinol-formaldehyde-hyperbranched PEI mesoporous catalyst, made by one-pot synthesis, was used successfully for in situ Suzuki-Miyaura cross coupling synthesis of anticancer prodrug PP-121 from iodoprazole and boronic ester precursors. The mesoporous catalyst wi...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2022-12, Vol.12 (12), p.1796
Main Authors: Nabavinia, Mahboubeh, Kanjilal, Baishali, Pandey, Manoj, Jonnalagadda, Subash, Hesketh, Robert, Martins-Green, Manuela, Noshadi, Iman
Format: Article
Language:English
Subjects:
anti cancer pro drug
Antimitotic agents
Antineoplastic agents
Antitumor agents
Apoptosis
Bioavailability
Biocompatibility
Cancer
Care and treatment
Catalysis
Catalysts
Cell culture
Cell proliferation
Cell viability
Chemistry
Chemotherapy
Cytotoxicity
Drug delivery
Flow cytometry
Gelatin
Gels (Pharmacy)
Gums and resins
Hydrogels
Hydrogels - pharmacology
mesoporous catalyst
onsite drug delivery
Palladium
Palladium - pharmacology
Production processes
Resorcinol
Software
Suzuki cross coupling
Testing
Tumors
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Summary:A heterogenous Palladium anchored Resorcinol-formaldehyde-hyperbranched PEI mesoporous catalyst, made by one-pot synthesis, was used successfully for in situ Suzuki-Miyaura cross coupling synthesis of anticancer prodrug PP-121 from iodoprazole and boronic ester precursors. The mesoporous catalyst with the non-cytotoxic precursors were tested in 2D in vitro model with excellent cytocompatibility and a strong suppression of PC3 cancer cell proliferation, underscored by 50% reduction in PC3 cells viability and 55% reduction in cell metabolism activity and an enhanced rate of early and late apoptosis in flow cytometry, that was induced only by successful in situ pro drug PP121 synthesis from the precursors. The 3D gelatin methacrylate hydrogel encapsulated in vitro cell models underscored the results with a 52% reduction in cell metabolism and underscored apoptosis of PC3 cells when the Pd anchored catalyst was combined with the precursors. In situ application of Suzuki-Miyaura cross coupling of non-cytotoxic precursors to cancer drug, along with their successful encapsulation in an injectable hydrogel could be applied for tumor point drug delivery strategies that can circumvent deleterious side effects and poor bioavailability chemotherapy routes with concomitant enhanced efficacy.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12121796