Frozen vs. fresh cycles IVF outcomes: retrospective study from an Indonesian IVF centre

To compare the live birth rates (LBR) and neonatal outcomes of frozen cycle in vitro fertilization (IVF) with fresh cycle IVF in the Indonesian population. This was retrospective study using secondary data of IVF patients at a private fertility centre. Study recruitment was between 3/8/2018 and 31/1...

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Bibliographic Details
Published in:BMC research notes 2021-05, Vol.14 (1), p.177-177, Article 177
Main Authors: Permadi, Wiryawan, Bayuaji, Hartanto, Tjandraprawira, Kevin Dominique, Tjahyadi, Dian, Harlianto, Harris, Achmad, Yanni Melliandari, Astarto, Nanang Winarto, Djuwantono, Tono
Format: Article
Language:English
Subjects:
Aged
Birth Rate
Comparative analysis
Embryo Transfer
Embryos
Endometriosis
Female
Fertility
Fertilization in Vitro
Frozen embryo transfer
Gestation
Humans
In vitro fertilization
Indonesia - epidemiology
Infant, Newborn
Infertility
Live Birth
Methods
Neonates
Ovaries
Patient outcomes
Patients
Polycystic ovary syndrome
Pregnancy
Recruitment
Reproductive technologies
Research Note
Retrospective Studies
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Summary:To compare the live birth rates (LBR) and neonatal outcomes of frozen cycle in vitro fertilization (IVF) with fresh cycle IVF in the Indonesian population. This was retrospective study using secondary data of IVF patients at a private fertility centre. Study recruitment was between 3/8/2018 and 31/12/2019. Total sampling included all patients undergoing oocyte retrieval and embryo transfer within recruitment period. Patients undergoing fresh IVF cycles and frozen IVF cycles were compared. 351 patients were recruited: 68.1% (239/351) underwent fresh cycles and 31.9% (112/351) frozen cycles. AMH was significantly higher in frozen cycle group (p = 0.04). Ovulatory disorder was significantly higher in frozen cycle group (p = 0.001). Among patients aged ≤ 30, fresh cycle group had significantly higher LBR (p = 0.02). Among those with ovulatory disorder, LBR was significantly higher with frozen cycle. No significant LBR difference was noted with other infertility causes. When stratified according to pregnancy order, frozen cycle patients had significantly higher birth lengths (p = 0.03) but not length of gestation nor neonatal birthweights. There was no significant difference in the proportion of biochemical pregnancy resulting in LBR (p = 0.08). To conclude, frozen cycle provided higher LBR among patients with ovulatory disorder but fresh cycle was beneficial among patients aged ≤ 30.
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-021-05585-w