Molecular Phylogenetic and Comparative Genomic Analysis of Pleurocordyceps fusiformispora sp. nov. and Perennicordyceps elaphomyceticola in the Family Polycephalomycetaceae

Several species have been reported as hyperparasitic fungi. A new species, , and a known species, , are described here based on morphology and phylogenetic evidence from six genes (ITS, SSU, LSU, , , and ). differed from the other species by producing flaky colonies, ovoid or elliptic α-conidia, and...

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Bibliographic Details
Published in:Journal of fungi (Basel) 2024-04, Vol.10 (4), p.297
Main Authors: Liu, Zuoheng, Lu, Yingling, Tang, Dexiang, Zhu, Juye, Luo, Lijun, Chen, Yue, Yu, Hong
Format: Article
Language:English
Subjects:
Biological activity
Biosynthesis
biosynthesis gene cluster
Brefeldin A
Conidia
Gene clusters
Genes
Genomes
Genomic analysis
Glucose
hyperparasitic fungi
Metabolites
Morphology
New species
Phylogeny
Piperazine
Polymerase chain reaction
Ribosomal DNA
RNA polymerase
secondary metabolite
Software
whole genome sequence
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Summary:Several species have been reported as hyperparasitic fungi. A new species, , and a known species, , are described here based on morphology and phylogenetic evidence from six genes (ITS, SSU, LSU, , , and ). differed from the other species by producing flaky colonies, ovoid or elliptic α-conidia, and fusiform or long fusiform β-conidia. Both full genomes of and were sequenced, annotated, and compared. The antiSMASH and local BLAST analyses revealed significant differences in the number and types of putative secondary metabolite biosynthetic gene clusters, i.e., NPPS, PKS, and hybrid PKS-NRPS domains, between the two species. In addition, the putative BGCs of six compounds, namely ε-poly lysine, 4-epi-15-epi-brefeldin A, Monorden D/monocillin IV/monocillin VII/pochonin M/monocillin V/monocillin II, Tolypyridone, Piperazine, and Triticone DABFC, were excavated in the present study. This study motivates the use of heterologous expression and gene knockout methods to discover novel biologically active SMs from Polycephalomycetaceae.
ISSN:2309-608X
2309-608X
DOI:10.3390/jof10040297