Meeting report, ICH M7 relevant workshop: use of (Q)SAR systems and expert judgment

Use of Quantitative Structure-Activity Relationships ((Q)SAR) prediction tools has been increasing since the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 guideline was issued in June 2014. The Japanese Environmental Mutagen Society and...

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Bibliographic Details
Published in:Genes and environment 2018-09, Vol.40 (1), p.1-7, Article 19
Main Authors: Mishima, Masayuki, Hashizume, Tsuneo, Haranosono, Yu, Nagato, Yusuke, Takeshita, Kentaro, Fukuchi, Junichi, Homma, Masamitsu
Format: Article
Language:English
Subjects:
Case studies
Cheminformatics
Expert judgment
Experts
Genetic research
Genotoxicity
ICH M7
In silico
Meeting Report
Metabolism
Mutagenesis
Mutagenicity
Pharmaceutical industry
QSAR
Salmonella
Structure-activity relationships
Toxicology
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Summary:Use of Quantitative Structure-Activity Relationships ((Q)SAR) prediction tools has been increasing since the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 guideline was issued in June 2014. The Japanese Environmental Mutagen Society and the Bacterial Mutagenicity Study Group took the initiative of the workshop on (Q)SAR in 2016 to discuss using (Q)SAR to predict mutagenicity. The aim of the workshop was to form a common understanding on the current use of (Q)SAR tools in industry and for regulatory purposes and on the process of expert judgment. This report summarizes the general session that reviewed the use of (Q)SAR tools and the case study session that discussed expert judgment.
ISSN:1880-7062
1880-7046
1880-7062
DOI:10.1186/s41021-018-0107-2