The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis

• Published in: Antimicrobial resistance & infection control 2023-01, Vol.12 (1), p.4-4, Article 4
• Main Authors: Hasanpour, Amir Hossein, Sepidarkish, Mahdi, Mollalo, Abolfazl, Ardekani, Ali, Almukhtar, Mustafa, Mechaal, Amal, Hosseini, Seyed Reza, Bayani, Masoumeh, Javanian, Mostafa, Rostami, Ali
• Format: Article
• Language: English
• Subjects: Age; Aged; Analysis; Antibiotics; Bias; Carrier State - epidemiology; Citation management software; Cohort analysis; Disease control; Drug resistance; Drug resistance in microorganisms; Elder care; Epidemiology; Health aspects; Humans; Infection; Long term health care; Long-term care; Long-term care of the sick; Male; Medical instruments; Meta-analysis; Methicillin; Methicillin-Resistant Staphylococcus aureus; Mortality; Multidrug resistant organisms; Nursing homes; Older people; Prevalence; Residential facilities; Review; Risk Factors; Staphylococcal Infections - epidemiology; Staphylococcus aureus; Staphylococcus aureus infections; Staphylococcus infections; Systematic review; World health
• ISSN: 2047-2994; 2047-2994
• DOI: 10.1186/s13756-023-01210-6

Methicillin-resistant Staphylococcus aureus (MRSA) is a difficult to treat infection, particularly in residents of elderly care centers (ECCs). Despite the substantial burden of MRSA, an inadequate number of studies have analyzed MRSA prevalence in ECCs. We conducted a worldwide systematic review and meta-analysis on the prevalence and risk factors of MRSA in ECCs. We searched MEDLINE/PubMed, EMBASE, Web of Science, and Scopus databases and the gray literature sources for all studies published between January 1980 and December 2022 on the prevalence of MRSA in ECCs. A random-effects model was utilized to estimate pooled prevalence rates at 95% confidence intervals (CI). Moreover, the data were analyzed based on World Health Organization-defined regions, income, and human development index levels. In total, 119 studies, including 164,717 participants from 29 countries, were found eligible for meta-analysis. The pooled global prevalence of MRSA was 14.69% (95% CI 12.39-17.15%; 16,793/164,717). Male gender [prevalence ratio (PR) = 1.55; 95% CI 1.47-1.64], previous MRSA infection (PR = 3.71; 95% CI 3.44-4.01), prior use of antibiotics (PR = 1.97; 95% CI 1.83-2.12), hospitalized within the previous year (PR = 1.32; 95% CI 1.20-1.45), have had any wound (PR = 2.38; 95% CI 2.23-2.55), have used urinary catheter (PR = 2.24; 95% CI 2.06-2.43), have used any medical device (PR = 1.78; 95% CI 1.66-1.91), and those with diabetes (PR = 1.55; CI 1.43-1.67) were more likely to be colonized by MRSA than other patients. Screening programs and preventive measures should target MRSA in ECCs due to the high global prevalence rates.