The Clinical Correlations of Helicobacter pylori Virulence Factors and Chronic Spontaneous Urticaria

Background and Study Aims. The association between Helicobacter pylori (H. pylori) and chronic spontaneous urticaria (CSU) remains controversial. This study explored the role of H. pylori in CSU among different virulent genotypes patients. Patients and Methods. Patients infected by H. pylori were so...

Full description

Saved in:
Bibliographic Details
Published in:Gastroenterology research and practice 2013-01, Vol.2013 (2013), p.1-6
Main Authors: Chiu, Yi-Chun, Tai, Wei-Chen, Chuah, Seng-Kee, Hsu, Ping-I, Wu, Deng-Chyang, Wu, Keng-Liang, Huang, Chao-Cheng, Ho, Ji-Chen, Ring, Johannes, Chen, Wen-Chieh
Format: Article
Language:English
Subjects:
Bacterial infections
Dermatology
Development and progression
Gastroenterology
Genes
Health aspects
Helicobacter pylori
Hospitals
Infections
Internal medicine
Medicine
Rosacea
Studies
Ulcers
University colleges
Urticaria
Virulence (Microbiology)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Study Aims. The association between Helicobacter pylori (H. pylori) and chronic spontaneous urticaria (CSU) remains controversial. This study explored the role of H. pylori in CSU among different virulent genotypes patients. Patients and Methods. Patients infected by H. pylori were sorted into two groups as group A (with CSU) and group B (without CSU). The tissue materials were taken via endoscopy for polymerase chain reaction study to determine virulence factors. After H. pylori eradication therapy, the eradication rate and response of urticaria were evaluated by using C13-UBT and a three-point scale (complete remission, partial remission, or no improvement). Results. The results were comparable between patients of groups A and B in terms of H. pylori infection rates and eradication rate. Longitudinal follow-up of 23.5 months showed complete remission of urticaria in 63.6% but no improvement in 36.4% of the patients after H. pylori eradication. H. pylori infected patients with different virulence factors such as cytotoxin-associated gene A, vacuolating cytotoxin gene A signal region and middle region have similar remission rates for CSU. Conclusions. Current study suggests that H. pylori may play a role in the development and disease course of CSU but may be irrelevant to different virulent genotypes.
ISSN:1687-6121
1687-630X
DOI:10.1155/2013/436727