Consumption of resistant starch decreases postprandial lipogenesis in white adipose tissue of the rat

Chronic consumption of diets high in resistant starch (RS) leads to reduced fat cell size compared to diets high in digestible starch (DS) in rats and increases total and meal fat oxidation in humans. The aim of the present study was to examine the rate of lipogenesis in key lipogenic organs followi...

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Bibliographic Details
Published in:Nutrition journal 2006-09, Vol.5 (1), p.25-25, Article 25
Main Authors: Higgins, Janine A, Brown, Marc A, Storlien, Leonard H
Format: Article
Language:English
Subjects:
Adipose Tissue - chemistry
Adipose Tissue - metabolism
Animals
Dietary Carbohydrates - administration & dosage
Digestion
Fatty Acids, Nonesterified - blood
Food
Glycogen - analysis
Kinetics
Lipids - analysis
Lipogenesis
Liver - chemistry
Liver - metabolism
Male
Muscle, Skeletal - chemistry
Muscle, Skeletal - metabolism
Rats
Rats, Wistar
Short Report
Starch - administration & dosage
Starch - metabolism
Triglycerides - blood
Tritium
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Summary:Chronic consumption of diets high in resistant starch (RS) leads to reduced fat cell size compared to diets high in digestible starch (DS) in rats and increases total and meal fat oxidation in humans. The aim of the present study was to examine the rate of lipogenesis in key lipogenic organs following a high RS or DS meal. Following an overnight fast, male Wistar rats ingested a meal with an RS content of 2% or 30% of total carbohydrate and were then administered an i.p bolus of 50 muCi 3H2O either immediately or 1 hour post-meal. One hour following tracer administration, rats were sacrificed, a blood sample collected, and the liver, white adipose tissue (WAT), and gastrocnemius muscle excised and frozen until assayed for total 3H-lipid and 3H-glycogen content. Plasma triglyceride and NEFA concentrations and 3H-glycogen content did not differ between groups. In all tissues, except the liver, there was a trend for the rate of lipogenesis to be higher in the DS group than the RS group which reached significance only in WAT at 1 h (p < 0.01). On a whole body level, this attenuation of fat deposition in WAT in response to a RS diet could be significant for the prevention of weight gain in the long-term.
ISSN:1475-2891
1475-2891
DOI:10.1186/1475-2891-5-25