Detection of cytotoxic activity of lectin on human colon adenocarcinoma (Sw480) and epithelial cervical carcinoma (C33-A)

Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was perfo...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2011-03, Vol.16 (3), p.2107-2118
Main Authors: Valadez-Vega, Carmen, Alvarez-Manilla, Gerardo, Riverón-Negrete, Leticia, García-Carrancá, Alejandro, Morales-González, José A, Zuñiga-Pérez, Clara, Madrigal-Santillán, Eduardo, Esquivel-Soto, Jaime, Esquivel-Chirino, Cesar, Villagómez-Ibarra, Roberto, Bautista, Mirandeli, Morales-González, Angel
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Cancer
Carbohydrates
Cell growth
Cell Proliferation - drug effects
Colonic Neoplasms - pathology
Cytotoxicity
Disease prevention
Drug Screening Assays, Antitumor
Electronic mail systems
Electrophoresis, Polyacrylamide Gel
Female
Humans
Lectins
Lectins - pharmacology
Neoplasms, Glandular and Epithelial - pathology
tepary bean lectins
tepary beans
Uterine Cervical Neoplasms - pathology
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Summary:Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent  effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules16032107