Assessing the short-term effects of radiotherapy on the shear modulus of the common carotid artery as a new biomarker of radiation-induced atherosclerosis

The purpose of this study was to investigate the incidence of short-term atherosclerosis in the common carotid arteries following radiotherapy. The mean radiation dose to the arteries was 49.30±15.83 Gy. A computational ultrasound method was introduced to investigate the elastic modulus. Ultrasonogr...

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Bibliographic Details
Published in:Ultrasonography (Seoul, Korea) Korea), 2022-01, Vol.41 (1), p.114-123
Main Authors: Mohammadkarim, Alireza, Mokhtari-Dizaji, Manijhe, Kazemian, Ali, Saberi, Hazhir, Yazdi, Niloofar Ayoobi, Esfehani, Mahbod
Format: Article
Language:English
Subjects:
Algorithms
Atherosclerosis
Biomarkers
Biomechanics
Blood pressure
Carotid arteries
carotid artery
Ethics
external radiotherapy
Flow velocity
image processing
Original
Patients
Radiation therapy
shear modulus
Shear strain
Shear stress
Tumors
Ultrasonic imaging
ultrasonography
Veins & arteries
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Summary:The purpose of this study was to investigate the incidence of short-term atherosclerosis in the common carotid arteries following radiotherapy. The mean radiation dose to the arteries was 49.30±15.83 Gy. A computational ultrasound method was introduced to investigate the elastic modulus. Ultrasonography was performed 2-3 cm inferior to the bifurcation region before and after radiotherapy, and sequential images were extracted from a video of each artery. Instantaneous movement of the arterial wall in the radial and longitudinal directions was extracted by implementing the maximum gradient and block matching algorithms, respectively. There was a significant change in systolic blood pressure after radiotherapy (P=0.008). Irradiated arteries had significantly smaller systolic and end-diastolic diameters than non-irradiated arteries (P
ISSN:2288-5919
2288-5943
DOI:10.14366/usg.21032