The prognostic ability of radiotherapy of different colorectal cancer histological subtypes and tumor sites

The prognostic significance of radiotherapy (RT) for colorectal cancer (CRC) has shown conflicting results, particularly among different pathological subtypes, including adenocarcinoma (AC), mucinous adenocarcinoma (MC), and signet-ring cell carcinoma (SR). This study analyzed the prognosis of three...

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Bibliographic Details
Published in:Scientific reports 2023-07, Vol.13 (1), p.11758-11758, Article 11758
Main Authors: Shi, Wenzai, Chen, Jianfei, Yao, Nan, Wu, Tiantian, Suo, Xiaopeng, Wang, Qiang, Liu, Jun, Yu, Guoyong, Zhang, Keming
Format: Article
Language:English
Subjects:
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Adenocarcinoma
Colorectal cancer
Colorectal carcinoma
Death
Epidemiology
Humanities and Social Sciences
Medical prognosis
Mortality
multidisciplinary
Radiation therapy
Regression analysis
Science
Science (multidisciplinary)
Tumors
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Summary:The prognostic significance of radiotherapy (RT) for colorectal cancer (CRC) has shown conflicting results, particularly among different pathological subtypes, including adenocarcinoma (AC), mucinous adenocarcinoma (MC), and signet-ring cell carcinoma (SR). This study analyzed the prognosis of three pathological CRC types and focused on the prognostic significance of RT on three CRC histological subtypes. Patients diagnosed with AC (n = 54,174), MC (n = 3813), and SR (n = 664) in the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database (2010–2017) were evaluated. Cox regression models and competitive risk models were built to assess the effect of RT on the risk of CRC-associated death. Potential interactions between RT and stratified variables including age, sex, and tumor location were examined by multiplicative models. Compared with AC patients, SR patients had the worst overall survival (OS) among 3 subtypes of CRC (log-rank test, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-38853-9