Genetic comparison of transmissible gastroenteritis coronaviruses

Transmissible gastroenteritis virus (TGEV) is a porcine coronavirus that threatens animal health and remains elusive despite years of research efforts. The systematical analysis of all available full-length genomes of TGEVs (a total of 43) and porcine respiratory coronaviruses PRCVs (a total of 7) s...

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Bibliographic Details
Published in:Frontiers in veterinary science 2023-04, Vol.10, p.1146648-1146648
Main Authors: Wang, Pei-Hua, Nawal Bahoussi, Amina, Tariq Shah, Pir, Guo, Yan-Yan, Wu, Changxin, Xing, Li
Format: Article
Language:English
Subjects:
China
coronavirus
phylogenetic tree
phylogeographic network
porcine respiratory coronavirus (PRCV)
transmissible gastroenteritis virus (TGEV)
Veterinary Science
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Summary:Transmissible gastroenteritis virus (TGEV) is a porcine coronavirus that threatens animal health and remains elusive despite years of research efforts. The systematical analysis of all available full-length genomes of TGEVs (a total of 43) and porcine respiratory coronaviruses PRCVs (a total of 7) showed that TGEVs fell into two independent evolutionary phylogenetic clades, GI and GII. Viruses circulating in China (until 2021) clustered with the traditional or attenuated vaccine strains within the same evolutionary clades (GI). In contrast, viruses latterly isolated in the USA fell into GII clade. The viruses circulating in China have a lower similarity with that isolated latterly in the USA all through the viral genome. In addition, at least four potential genomic recombination events were identified, three of which occurred in GI clade and one in GII clade. TGEVs circulating in China are distinct from the viruses latterly isolated in the USA at either genomic nucleotide or antigenic levels. Genomic recombination serves as a factor driving the expansion of TGEV genomic diversity.
ISSN:2297-1769
2297-1769
DOI:10.3389/fvets.2023.1146648