Prognosis of acute myeloid leukemia harboring monosomal karyotype in patients treated with or without allogeneic hematopoietic cell transplantation after achieving complete remission

To evaluate the prognostic impact of monosomal karyotype on post-remission outcome in acute myeloid leukemia, we retrospectively analyzed 2,099 patients who had achieved complete remission. Monosomal karyotype was noted in 73 patients (4%). Of these, the probability of overall survival from first co...

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Bibliographic Details
Published in:Haematologica (Roma) 2012-06, Vol.97 (6), p.915-918
Main Authors: YANADA, Masamitsu, KUROSAWA, Saiko, TAKAMATSU, Yasushi, WAKI, Fusako, YOKOYAMA, Hiroki, WATANABE, Masato, EMI, Nobuhiko, FUKUDA, Takahiro, YAMAGUCHI, Takuhiro, YAMASHITA, Takuya, MORIUCHI, Yukiyoshi, AGO, Hiroatsu, TAKEUCHI, Jin, NAKAMAE, Hirohisa, TAGUCHI, Jun, SAKURA, Toru
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Chromosome aberrations
Female
Hematologic and hematopoietic diseases
Hematopoietic Stem Cell Transplantation
Humans
Karyotyping
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - mortality
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical genetics
Medical sciences
Middle Aged
Monosomy - diagnosis
Monosomy - genetics
Original and Brief Reports
Recurrence
Remission Induction
Retrospective Studies
Survival Rate
Transplantation, Homologous
Treatment Outcome
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Summary:To evaluate the prognostic impact of monosomal karyotype on post-remission outcome in acute myeloid leukemia, we retrospectively analyzed 2,099 patients who had achieved complete remission. Monosomal karyotype was noted in 73 patients (4%). Of these, the probability of overall survival from first complete remission was 14% at four years, which was significantly lower than that reported in patients without monosomal karyotype, primarily due to a high relapse rate (86%). Monosomal karyotype remained significantly associated with worse overall survival among patients with unfavorable cytogenetics or complex karyotype, and even in patients who underwent allogeneic hematopoietic cell transplantation during first complete remission. These findings confirm that monosomal karyotype has a significantly adverse effect on post-remission outcome in patients with acute myeloid leukemia treated with and without allogeneic hematopoietic cell transplantation in first complete remission, emphasizing the need for the development of alternative therapies for this patient population.
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.2011.058289