Prognosis of acute myeloid leukemia harboring monosomal karyotype in patients treated with or without allogeneic hematopoietic cell transplantation after achieving complete remission

• Published in: Haematologica (Roma) 2012-06, Vol.97 (6), p.915-918
• Main Authors: YANADA, Masamitsu, KUROSAWA, Saiko, TAKAMATSU, Yasushi, WAKI, Fusako, YOKOYAMA, Hiroki, WATANABE, Masato, EMI, Nobuhiko, FUKUDA, Takahiro, YAMAGUCHI, Takuhiro, YAMASHITA, Takuya, MORIUCHI, Yukiyoshi, AGO, Hiroatsu, TAKEUCHI, Jin, NAKAMAE, Hirohisa, TAGUCHI, Jun, SAKURA, Toru
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - therapeutic use; Biological and medical sciences; Chromosome aberrations; Female; Hematologic and hematopoietic diseases; Hematopoietic Stem Cell Transplantation; Humans; Karyotyping; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - mortality; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical genetics; Medical sciences; Middle Aged; Monosomy - diagnosis; Monosomy - genetics; Original and Brief Reports; Recurrence; Remission Induction; Retrospective Studies; Survival Rate; Transplantation, Homologous; Treatment Outcome
• ISSN: 0390-6078; 1592-8721
• DOI: 10.3324/haematol.2011.058289

To evaluate the prognostic impact of monosomal karyotype on post-remission outcome in acute myeloid leukemia, we retrospectively analyzed 2,099 patients who had achieved complete remission. Monosomal karyotype was noted in 73 patients (4%). Of these, the probability of overall survival from first complete remission was 14% at four years, which was significantly lower than that reported in patients without monosomal karyotype, primarily due to a high relapse rate (86%). Monosomal karyotype remained significantly associated with worse overall survival among patients with unfavorable cytogenetics or complex karyotype, and even in patients who underwent allogeneic hematopoietic cell transplantation during first complete remission. These findings confirm that monosomal karyotype has a significantly adverse effect on post-remission outcome in patients with acute myeloid leukemia treated with and without allogeneic hematopoietic cell transplantation in first complete remission, emphasizing the need for the development of alternative therapies for this patient population.