The lysosomal trafficking regulator "LYST": an 80-year traffic jam

Lysosomes and lysosome related organelles (LROs) are dynamic organelles at the intersection of various pathways involved in maintaining cellular hemostasis and regulating cellular functions. Vesicle trafficking of lysosomes and LROs are critical to maintain their functions. The lysosomal trafficking...

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Bibliographic Details
Published in:Frontiers in immunology 2024-05, Vol.15, p.1404846
Main Authors: Turner, Mackenzie E, Che, Jingru, Mirhaidari, Gabriel J M, Kennedy, Catherine C, Blum, Kevin M, Rajesh, Sahana, Zbinden, Jacob C, Breuer, Christopher K, Best, Cameron A, Barker, Jenny C
Format: Article
Language:English
Subjects:
Animals
cancer
Chediak-Higashi Syndrome - genetics
Chédiak-Higashi syndrome
Humans
Immunology
immunotherapy
lysosomes
Lysosomes - metabolism
Mutation
Protein Transport
vesicle traffic
Vesicular Transport Proteins - genetics
Vesicular Transport Proteins - metabolism
wound healing
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Summary:Lysosomes and lysosome related organelles (LROs) are dynamic organelles at the intersection of various pathways involved in maintaining cellular hemostasis and regulating cellular functions. Vesicle trafficking of lysosomes and LROs are critical to maintain their functions. The lysosomal trafficking regulator (LYST) is an elusive protein important for the regulation of membrane dynamics and intracellular trafficking of lysosomes and LROs. Mutations to the LYST gene result in Chédiak-Higashi syndrome, an autosomal recessive immunodeficiency characterized by defective granule exocytosis, cytotoxicity, etc. Despite eight decades passing since its initial discovery, a comprehensive understanding of LYST's function in cellular biology remains unresolved. Accumulating evidence suggests that dysregulation of LYST function also manifests in other disease states. Here, we review the available literature to consolidate available scientific endeavors in relation to LYST and discuss its relevance for immunomodulatory therapies, regenerative medicine and cancer applications.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1404846