Indoor-related microbe damage induces complement system activation in building users

In this comparative study, serum complement system antimicrobial activity was measured from 159 serum samples, taken from individuals from microbe-damaged (70 samples) and from reference buildings (89 samples). Antimicrobial activity was assessed using a probe-based bacterial Escherichia coli-lux bi...

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Bibliographic Details
Published in:Innate immunity (London, England) England), 2021-01, Vol.27 (1), p.15-22
Main Authors: Atosuo, Janne, Karhuvaara, Outi, Suominen, Eetu, Vilén, Liisa, Nuutila, Jari, Putus, Tuula
Format: Article
Language:English
Subjects:
Air Microbiology
Antimicrobial activity
Antimicrobial agents
Bacteria
Bacterial Load
Bioluminescence
Blood Bactericidal Activity - immunology
Colony Count, Microbial
Complement activation
Complement Pathway, Alternative
Complement Pathway, Classical
Complement System Proteins - immunology
Escherichia coli
Fungi
Humans
Inflammation
Microorganisms
Original
Reference Values
Sick Building Syndrome - immunology
Sick Building Syndrome - microbiology
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Summary:In this comparative study, serum complement system antimicrobial activity was measured from 159 serum samples, taken from individuals from microbe-damaged (70 samples) and from reference buildings (89 samples). Antimicrobial activity was assessed using a probe-based bacterial Escherichia coli-lux bioluminescence system and comparison was made at a group level between the experimental and reference group. The complement activity was higher in users of microbe-damaged buildings compared with the reference group and the significant (P 
ISSN:1753-4259
1753-4267
DOI:10.1177/1753425920966641