Distinct roles of amylin and oxytocin signaling in intrafamilial social behaviors at the medial preoptic area of common marmosets

Calcitonin receptor (Calcr) and its brain ligand amylin in the medial preoptic area (MPOA) are found to be critically involved in infant care and social contact behaviors in mice. In primates, however, the evidence is limited to an excitotoxic lesion study of the Calcr-expressing MPOA subregion (cMP...

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Published in:Communications biology 2023-12, Vol.6 (1), p.1231-1231, Article 1231
Main Authors: Kurachi, Takuma, Shinozuka, Kazutaka, Yoshihara, Chihiro, Yano-Nashimoto, Saori, Murayama, Ayako Y., Hata, Junichi, Haga, Yawara, Okano, Hideyuki, Kuroda, Kumi O.
Format: Article
Language:English
Subjects:
38/1
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631/378/2645/2646
631/378/3919
631/601/18
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Amylin
Animals
Biomedical and Life Sciences
Callithrix
Child care
Drug Inverse Agonism
Excitotoxicity
Hormones
Humans
Hypothalamus
Infants
Inverse agonists
Islet Amyloid Polypeptide
Life Sciences
Mice
Oxytocin
Oxytocin - pharmacology
Paraventricular nucleus
Preoptic Area
Preoptic area (medial)
Social Behavior
Social interactions
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Summary:Calcitonin receptor (Calcr) and its brain ligand amylin in the medial preoptic area (MPOA) are found to be critically involved in infant care and social contact behaviors in mice. In primates, however, the evidence is limited to an excitotoxic lesion study of the Calcr-expressing MPOA subregion (cMPOA) in a family-living primate species, the common marmoset. The present study utilized pharmacological manipulations of the cMPOA and shows that reversible inactivation of the cMPOA abolishes infant-care behaviors in sibling marmosets without affecting other social or non-social behaviors. Amylin-expressing neurons in the marmoset MPOA are distributed in the vicinity of oxytocin neurons in the anterior paraventricular nucleus of the hypothalamus. While amylin infusion facilitates infant carrying selectively, an oxytocin’s inverse agonist, atosiban, reduces physical contact with non-infant family members without grossly affecting infant care. These data suggest that the amylin and oxytocin signaling mediate intrafamilial social interactions in a complementary manner in marmosets. Amylin facilitates infant care and oxytocin’s inverse agonist reduces physical contact with non-infant family member, so these signaling mediate social interaction in family in complementary manner.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-023-05593-5