Joint modeling of time to diabetic retinopathy and change in fasting blood sugar among type 2 diabetic patients, Northwest Ethiopia

This study aimed to assess changes in fasting blood sugar (FBS) levels, time to diabetic retinopathy (DR) and its predictors among type 2 diabetes patients in Ethiopia. An institution-based retrospective follow-up study was conducted at the University of Gondar Comprehensive Specialized Hospital. Th...

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Bibliographic Details
Published in:Scientific reports 2022-02, Vol.12 (1), p.2236-9, Article 2236
Main Authors: Kebede, Sewnet Adem, Tessema, Zemenu Tadesse, Balcha, Shitaye Alemu, Ayele, Tadesse Awoke
Format: Article
Language:English
Subjects:
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Aged
Antidiabetics
Blood
Blood Glucose - analysis
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - epidemiology
Diabetic retinopathy
Diabetic Retinopathy - blood
Diabetic Retinopathy - epidemiology
Ethiopia - epidemiology
Fasting
Fasting - blood
Female
Follow-Up Studies
Hospitals, University
Humanities and Social Sciences
Humans
Hypertension
Hypoglycemic Agents - therapeutic use
Incidence
Kaplan-Meier Estimate
Laboratory testing
Male
Middle Aged
Models, Statistical
multidisciplinary
Patients
Proportional Hazards Models
Regression Analysis
Retinopathy
Retrospective Studies
Risk Factors
Science
Science (multidisciplinary)
Sugar
Time Factors
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Summary:This study aimed to assess changes in fasting blood sugar (FBS) levels, time to diabetic retinopathy (DR) and its predictors among type 2 diabetes patients in Ethiopia. An institution-based retrospective follow-up study was conducted at the University of Gondar Comprehensive Specialized Hospital. The linear mixed effect model and Cox proportional hazard models were fitted separately, and later, the two models were fitted jointly using R software. Variables with a p value  1 antidiabetic oral agent (AHR = 4.90; 95% CI 1.07–20.0) and more than 10 years duration (AHR = 0.17, 95% CI 0.06–0.46) were predictors of time to DR. This study revealed that the current value of FBS and the rate of FBS change were significantly associated with the time to DR.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-06240-5