Effects of Deep Hyperthermia Combined with Intraperitoneal Chemotherapy on Liver-Kidney Function, Immune Function, and Long-Term Survival in Patients with Abdominal Metastases

• Published in: Emergency medicine international 2023-04, Vol.2023, p.5878402-7
• Main Authors: Zhang, Yan, Lu, Xiaomin, Ji, Haoming, Zheng, Liangfeng, Chen, Guodong, Qian, Ye
• Format: Article
• Language: English
• Subjects: Cancer; Care and treatment; Chemotherapy; Complications and side effects; Fever; Hyperthermia; Liver; Liver diseases; Metastasis; Patient outcomes
• ISSN: 2090-2840; 2090-2859
• DOI: 10.1155/2023/5878402

Objectives. To analyze the effects of deep hyperthermia combined with intraperitoneal chemotherapy on liver-kidney function, immune function, and long-term survival in patients with abdominal metastases. Methods. A total of 88 patients with abdominal metastases confirmed in the hospital were enrolled as the research objects between August 2018 and August 2021. They were randomly divided into control group (n = 44) and observation group (n = 44). The control group was treated with intraperitoneal chemotherapy, while observation group was additionally treated with deep hyperthermia. The general clinical data of patients were recorded. The short-term and long-term curative effects were evaluated. The occurrence of side effects in both groups was recorded. Before and after treatment, levels of alanine transaminase (ALT) and aspartate transaminase (AST) were detected by full-automatic biochemical analyzer. The level of blood urea nitrogen (BUN) was detected by the urease electrode method. The level of serum creatinine (Scr) was detected by the picric acid method. The levels of CD3+, CD4+, CD8+, and NK cells were detected by BD FACSCalibur flow cytometer. Results. There was no significant difference in clinical data between the two groups (P>0.05). In the observation group, ORR was significantly higher than that in the control group (54.55% vs 29.55%) (P