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Aseptic meningitis epidemic during a West Nile virus avian epizootic
While enteroviruses have been the most commonly identified cause of aseptic meningitis in the United States, the role of the emerging, neurotropic West Nile virus (WNV) is not clear. In summer 2001, an aseptic meningitis epidemic occurring in an area of a WNV epizootic in Baltimore, Maryland, was in...
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| Published in: | Emerging infectious diseases 2003-09, Vol.9 (9), p.1082-1088 |
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| container_title | Emerging infectious diseases |
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| creator | Julian, Kathleen G Mullins, James A Olin, Annette Peters, Heather Nix, W Allan Oberste, M Steven Lovchik, Judith C Bergmann, Amy Brechner, Ross J Myers, Robert A Marfin, Anthony A Campbell, Grant L |
| description | While enteroviruses have been the most commonly identified cause of aseptic meningitis in the United States, the role of the emerging, neurotropic West Nile virus (WNV) is not clear. In summer 2001, an aseptic meningitis epidemic occurring in an area of a WNV epizootic in Baltimore, Maryland, was investigated to determine the relative contributions of WNV and enteroviruses. A total of 113 aseptic meningitis cases with onsets from June 1 to September 30, 2001, were identified at six hospitals. WNV immunoglobulin M tests were negative for 69 patients with available specimens; however, 43 (61%) of 70 patients tested enterovirus-positive by viral culture or polymerase chain reaction. Most (76%) of the serotyped enteroviruses were echoviruses 13 and 18. Enteroviruses, including previously rarely detected echoviruses, likely caused most aseptic meningitis cases in this epidemic. No WNV meningitis cases were identified. Even in areas of WNV epizootics, enteroviruses continue to be important causative agents of aseptic meningitis. |
| doi_str_mv | 10.3201/eid0909.030068 |
| format | article |
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In summer 2001, an aseptic meningitis epidemic occurring in an area of a WNV epizootic in Baltimore, Maryland, was investigated to determine the relative contributions of WNV and enteroviruses. A total of 113 aseptic meningitis cases with onsets from June 1 to September 30, 2001, were identified at six hospitals. WNV immunoglobulin M tests were negative for 69 patients with available specimens; however, 43 (61%) of 70 patients tested enterovirus-positive by viral culture or polymerase chain reaction. Most (76%) of the serotyped enteroviruses were echoviruses 13 and 18. Enteroviruses, including previously rarely detected echoviruses, likely caused most aseptic meningitis cases in this epidemic. No WNV meningitis cases were identified. 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Even in areas of WNV epizootics, enteroviruses continue to be important causative agents of aseptic meningitis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>aseptic</subject><subject>Baltimore - epidemiology</subject><subject>Birds</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Communicable diseases in animals</subject><subject>Communicable Diseases, Emerging - epidemiology</subject><subject>Communicable Diseases, Emerging - virology</subject><subject>Diagnosis</subject><subject>Disease Outbreaks</subject><subject>echovirus infections</subject><subject>Enterovirus</subject><subject>Enterovirus - isolation & purification</subject><subject>Enterovirus - pathogenicity</subject><subject>enterovirus infections</subject><subject>Enterovirus Infections - epidemiology</subject><subject>epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Meningitis</subject><subject>Meningitis, Aseptic - epidemiology</subject><subject>Meningitis, Aseptic - virology</subject><subject>Middle Aged</subject><subject>Population Surveillance</subject><subject>Serotyping</subject><subject>West Nile fever</subject><subject>West Nile virus</subject><subject>West Nile virus - isolation & purification</subject><subject>West Nile virus - pathogenicity</subject><issn>1080-6040</issn><issn>1080-6059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqNkstr3DAQxk1padK01x6LT4EevB3Zel4KS_paCA30eRSyNPYqeK2tZS9J__oqu0uahYUWHSRGv-8baWay7CWBWVUCeYPegQI1gwqAy0fZKQEJBQemHt-fKZxkz2K8BiBJop5mJ4QyokpKT7N384jr0dt8hb3vWz_6mOPaO1ylmJuGFMtN_hPjmH_2HeYbP0wxNxtv-jvudwhJ_Dx70pgu4ov9fpZ9__D-28Wn4vLq4-JifllYztRYCO5q6UhDiSOsrhh13CjJKykFUMINaYhxUpXKQC1R2JK5UtRGsNLWBKiqzrLFztcFc63Xg1-Z4VYH4_U2EIZWmyG9p0MNhNAmVcHx0lJqaM0RVC1KKK2oUlmS19ud13qqV-gs9uNgugPTw5veL3UbNroCwoWkyeB8bzCEX1MqkF75aLHrTI9hilowQamU5J8gEYyWleAJLHZga9IPfN-ElNi22GPKH3psUgP0PDWVU8G2X5gd4dPadu-o4PWBIDEj3oytmWLUi69f_p-9-nHInj9gl2i6cRlDN40-9PHoi-0QYhywua83AX03z3o_z3o3z0nw6mGX_uL7Aa7-AMI37Aw</recordid><startdate>200309</startdate><enddate>200309</enddate><creator>Julian, Kathleen G</creator><creator>Mullins, James A</creator><creator>Olin, Annette</creator><creator>Peters, Heather</creator><creator>Nix, W Allan</creator><creator>Oberste, M Steven</creator><creator>Lovchik, Judith C</creator><creator>Bergmann, Amy</creator><creator>Brechner, Ross J</creator><creator>Myers, Robert A</creator><creator>Marfin, Anthony A</creator><creator>Campbell, Grant L</creator><general>U.S. National Center for Infectious Diseases</general><general>Centers for Disease Control and Prevention</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>200309</creationdate><title>Aseptic meningitis epidemic during a West Nile virus avian epizootic</title><author>Julian, Kathleen G ; Mullins, James A ; Olin, Annette ; Peters, Heather ; Nix, W Allan ; Oberste, M Steven ; Lovchik, Judith C ; Bergmann, Amy ; Brechner, Ross J ; Myers, Robert A ; Marfin, Anthony A ; Campbell, Grant L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c659t-76db8d1f41d15b354d6a98638870416a1f1ad8929a0b8e7c25d27ba752cb10493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>aseptic</topic><topic>Baltimore - epidemiology</topic><topic>Birds</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Communicable diseases in animals</topic><topic>Communicable Diseases, Emerging - epidemiology</topic><topic>Communicable Diseases, Emerging - virology</topic><topic>Diagnosis</topic><topic>Disease Outbreaks</topic><topic>echovirus infections</topic><topic>Enterovirus</topic><topic>Enterovirus - isolation & purification</topic><topic>Enterovirus - pathogenicity</topic><topic>enterovirus infections</topic><topic>Enterovirus Infections - epidemiology</topic><topic>epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Meningitis</topic><topic>Meningitis, Aseptic - epidemiology</topic><topic>Meningitis, Aseptic - virology</topic><topic>Middle Aged</topic><topic>Population Surveillance</topic><topic>Serotyping</topic><topic>West Nile fever</topic><topic>West Nile virus</topic><topic>West Nile virus - isolation & purification</topic><topic>West Nile virus - pathogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Julian, Kathleen G</creatorcontrib><creatorcontrib>Mullins, James A</creatorcontrib><creatorcontrib>Olin, Annette</creatorcontrib><creatorcontrib>Peters, Heather</creatorcontrib><creatorcontrib>Nix, W Allan</creatorcontrib><creatorcontrib>Oberste, M Steven</creatorcontrib><creatorcontrib>Lovchik, Judith C</creatorcontrib><creatorcontrib>Bergmann, Amy</creatorcontrib><creatorcontrib>Brechner, Ross J</creatorcontrib><creatorcontrib>Myers, Robert A</creatorcontrib><creatorcontrib>Marfin, Anthony A</creatorcontrib><creatorcontrib>Campbell, Grant L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Science in Context</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>Emerging infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Julian, Kathleen G</au><au>Mullins, James A</au><au>Olin, Annette</au><au>Peters, Heather</au><au>Nix, W Allan</au><au>Oberste, M Steven</au><au>Lovchik, Judith C</au><au>Bergmann, Amy</au><au>Brechner, Ross J</au><au>Myers, Robert A</au><au>Marfin, Anthony A</au><au>Campbell, Grant L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aseptic meningitis epidemic during a West Nile virus avian epizootic</atitle><jtitle>Emerging infectious diseases</jtitle><addtitle>Emerg Infect Dis</addtitle><date>2003-09</date><risdate>2003</risdate><volume>9</volume><issue>9</issue><spage>1082</spage><epage>1088</epage><pages>1082-1088</pages><issn>1080-6040</issn><eissn>1080-6059</eissn><abstract>While enteroviruses have been the most commonly identified cause of aseptic meningitis in the United States, the role of the emerging, neurotropic West Nile virus (WNV) is not clear. In summer 2001, an aseptic meningitis epidemic occurring in an area of a WNV epizootic in Baltimore, Maryland, was investigated to determine the relative contributions of WNV and enteroviruses. A total of 113 aseptic meningitis cases with onsets from June 1 to September 30, 2001, were identified at six hospitals. WNV immunoglobulin M tests were negative for 69 patients with available specimens; however, 43 (61%) of 70 patients tested enterovirus-positive by viral culture or polymerase chain reaction. Most (76%) of the serotyped enteroviruses were echoviruses 13 and 18. Enteroviruses, including previously rarely detected echoviruses, likely caused most aseptic meningitis cases in this epidemic. No WNV meningitis cases were identified. Even in areas of WNV epizootics, enteroviruses continue to be important causative agents of aseptic meningitis.</abstract><cop>United States</cop><pub>U.S. National Center for Infectious Diseases</pub><pmid>14519244</pmid><doi>10.3201/eid0909.030068</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central |
| subjects | Adolescent Adult Aged Animals aseptic Baltimore - epidemiology Birds Child Child, Preschool Communicable diseases in animals Communicable Diseases, Emerging - epidemiology Communicable Diseases, Emerging - virology Diagnosis Disease Outbreaks echovirus infections Enterovirus Enterovirus - isolation & purification Enterovirus - pathogenicity enterovirus infections Enterovirus Infections - epidemiology epidemiology Female Humans Infant Infant, Newborn Male Meningitis Meningitis, Aseptic - epidemiology Meningitis, Aseptic - virology Middle Aged Population Surveillance Serotyping West Nile fever West Nile virus West Nile virus - isolation & purification West Nile virus - pathogenicity |
| title | Aseptic meningitis epidemic during a West Nile virus avian epizootic |
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