Serum Level of Antibody against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in People Dermally Exposed to PAHs

Some specific antibodies indicate the presence of antigenic structures on DNA (DNA adducts) that can play an important role in the process of mutagenesis and/or carcinogenesis. They indicate the presence of increased genotoxic potential (hazard) prior to the formation of disease (primary prevention)...

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Bibliographic Details
Published in:Journal of immunology research 2014-01, Vol.2014 (2014), p.1-6
Main Authors: Fiala, Zdenek, Borsky, Pavel, Hamakova, Kvetoslava, Chmelarova, Marcela, Palicka, Vladimir, Krejsek, Jan, Andrys, Ctirad, Borska, Lenka, Kremláček, J.
Format: Article
Language:English
Subjects:
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Adolescent
Adult
Age
Aged
Antibodies - blood
Antigens
Biomarkers
Biomarkers - blood
Carcinogens
Coal Tar - therapeutic use
Deoxyribonucleic acid
DNA
DNA Adducts - blood
DNA Adducts - immunology
Female
Hospitals
Humans
Immunology
Male
Medicine
Middle Aged
Mutagenesis
Patients
Polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - toxicity
Psoriasis
Psoriasis - blood
Psoriasis - immunology
Psoriasis - pathology
Psoriasis - therapy
Sexually transmitted diseases
Skin - drug effects
Skin - immunology
Smoking
Smoking - blood
STD
Studies
Tumors
Ultraviolet Therapy
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Summary:Some specific antibodies indicate the presence of antigenic structures on DNA (DNA adducts) that can play an important role in the process of mutagenesis and/or carcinogenesis. They indicate the presence of increased genotoxic potential (hazard) prior to the formation of disease (primary prevention). The present study was focused on the serum level of benzo[a]pyrene 7,8-diol-9,10-epoxide-DNA adducts antibodies (anti-BPDE-DNA) in psoriatic patients ( n = 55 ) dermally exposed to different levels of polycyclic aromatic hydrocarbons (PAHs). The general goal of the study was to contribute to better understanding of the value of the assumed biomarker (anti-BPDE-DNA) for evaluation of the organism's answer to genotoxic exposure to PAHs. Elevated level of exposure to PAHs resulted in the increased level of anti-BPDE-DNA. However, almost all levels of anti-BPDE-DNA ranged within the field of low values. Both variants of GT (CCT-3% and CCT-5%) induced higher expression of anti-BPDE-DNA in the group of nonsmokers. Significant relations between the level of anti-BPDE-DNA and PASI score, total duration of the therapy, or time of UVR exposure were not found. Further studies are needed to reduce interpretation uncertainty of this promising bioindicator.
ISSN:2314-8861
2314-7156
DOI:10.1155/2014/834389