Investigating the impact of clinical and genetic factors on the post-surgery prognosis of sinonasal squamous cell carcinoma

Sinonasal squamous cell carcinoma (SNSCC) is an aggressive cancer affecting the nasal and sinus regions, with its progression factors, particularly genetic ones, not yet fully understood. Here, we first conducted a retrospective study with 219 SNSCC patients to identify clinical factors affecting SN...

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Bibliographic Details
Published in:Scientific reports 2024-09, Vol.14 (1), p.22167-12, Article 22167
Main Authors: Lian, Meng, Han, Boxuan, Chen, Jiaming, Shen, Xixi, Zhao, Yanming, Shi, Qian, Feng, Ling, He, Shizhi, Ma, Hongzhi, Hou, Lizhen, Zhong, Qi, Cao, Hongbao, Fang, Jugao
Format: Article
Language:English
Subjects:
631/67/1059
631/67/1536
Adult
Aged
Aged, 80 and over
Apoptosis
Bcl-2 protein
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
ErbB-2 protein
Female
Gene Expression Regulation, Neoplastic
Gene set enrichment analysis
Genes
Genetic analysis
Genetic factor
Genetic factors
Head & neck cancer
Humanities and Social Sciences
Humans
Male
Medical prognosis
Middle Aged
multidisciplinary
Neoplasm Recurrence, Local - genetics
Neoplasm Staging
Nose
Overall survival
Paranasal Sinus Neoplasms - genetics
Paranasal Sinus Neoplasms - mortality
Paranasal Sinus Neoplasms - pathology
Paranasal Sinus Neoplasms - surgery
Patients
Prognosis
Prognosis analysis
PTEN protein
Recurrence-free survival
Retrospective Studies
Science
Science (multidisciplinary)
Sinus
SNSCC
Squamous cell carcinoma
Surgery
Tumors
Citations: Items that this one cites
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Description
Summary:Sinonasal squamous cell carcinoma (SNSCC) is an aggressive cancer affecting the nasal and sinus regions, with its progression factors, particularly genetic ones, not yet fully understood. Here, we first conducted a retrospective study with 219 SNSCC patients to identify clinical factors affecting SNSCC prognosis. Additionally, we mined a vast literature dataset to uncover genetic factors associated with SNSCC progression. Based on this data, we constructed SNSCC prognosis pathways and performed a gene set enrichment analysis (GSEA). Clear operative margins were linked to a 73.5–86.3% improvement in overall survival and a 73.5–88.9% lower risk of recurrence. Nasal cavity-originated cases exhibited a 67.6–97.4% decrease in mortality and an 80.7–96.7% lower recurrence rate. Patients at T1-2 staging had a 65.0–80.6% reduced risk of death and recurrence compared to those at T3 stage. Additionally, we identified 53 genes associated with SNSCC, with 14 also implicated in primary tumor site, T stage, and operative margin. These genes, including EGFR, PIK3CA, ERBB2, PTEN, BCL2, BRAF, KRAS, and PRL, form a complex SNSCC-prognosis pathway and were significantly enriched in 42 KEGG pathways and Gene Ontology (GO) terms (FDR-corrected p-value 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-73157-6