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Investigating the impact of clinical and genetic factors on the post-surgery prognosis of sinonasal squamous cell carcinoma
Sinonasal squamous cell carcinoma (SNSCC) is an aggressive cancer affecting the nasal and sinus regions, with its progression factors, particularly genetic ones, not yet fully understood. Here, we first conducted a retrospective study with 219 SNSCC patients to identify clinical factors affecting SN...
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| Published in: | Scientific reports 2024-09, Vol.14 (1), p.22167-12, Article 22167 |
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| creator | Lian, Meng Han, Boxuan Chen, Jiaming Shen, Xixi Zhao, Yanming Shi, Qian Feng, Ling He, Shizhi Ma, Hongzhi Hou, Lizhen Zhong, Qi Cao, Hongbao Fang, Jugao |
| description | Sinonasal squamous cell carcinoma (SNSCC) is an aggressive cancer affecting the nasal and sinus regions, with its progression factors, particularly genetic ones, not yet fully understood. Here, we first conducted a retrospective study with 219 SNSCC patients to identify clinical factors affecting SNSCC prognosis. Additionally, we mined a vast literature dataset to uncover genetic factors associated with SNSCC progression. Based on this data, we constructed SNSCC prognosis pathways and performed a gene set enrichment analysis (GSEA). Clear operative margins were linked to a 73.5–86.3% improvement in overall survival and a 73.5–88.9% lower risk of recurrence. Nasal cavity-originated cases exhibited a 67.6–97.4% decrease in mortality and an 80.7–96.7% lower recurrence rate. Patients at T1-2 staging had a 65.0–80.6% reduced risk of death and recurrence compared to those at T3 stage. Additionally, we identified 53 genes associated with SNSCC, with 14 also implicated in primary tumor site, T stage, and operative margin. These genes, including EGFR, PIK3CA, ERBB2, PTEN, BCL2, BRAF, KRAS, and PRL, form a complex SNSCC-prognosis pathway and were significantly enriched in 42 KEGG pathways and Gene Ontology (GO) terms (FDR-corrected p-value |
| doi_str_mv | 10.1038/s41598-024-73157-6 |
| format | article |
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Here, we first conducted a retrospective study with 219 SNSCC patients to identify clinical factors affecting SNSCC prognosis. Additionally, we mined a vast literature dataset to uncover genetic factors associated with SNSCC progression. Based on this data, we constructed SNSCC prognosis pathways and performed a gene set enrichment analysis (GSEA). Clear operative margins were linked to a 73.5–86.3% improvement in overall survival and a 73.5–88.9% lower risk of recurrence. Nasal cavity-originated cases exhibited a 67.6–97.4% decrease in mortality and an 80.7–96.7% lower recurrence rate. Patients at T1-2 staging had a 65.0–80.6% reduced risk of death and recurrence compared to those at T3 stage. Additionally, we identified 53 genes associated with SNSCC, with 14 also implicated in primary tumor site, T stage, and operative margin. These genes, including EGFR, PIK3CA, ERBB2, PTEN, BCL2, BRAF, KRAS, and PRL, form a complex SNSCC-prognosis pathway and were significantly enriched in 42 KEGG pathways and Gene Ontology (GO) terms (FDR-corrected p-value < 0.001), influencing cell growth, apoptosis, and oncogenic signaling pathways. Our study suggests that three clinical parameters (operative margin type, primary tumor site, and T-stage) and 14 genetic factors may influence SNSCC prognosis post-surgery. These findings deepen our understanding of SNSCC and offer potential avenues to enhance its treatment and outcomes.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-024-73157-6</identifier><identifier>PMID: 39333222</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/1059 ; 631/67/1536 ; Adult ; Aged ; Aged, 80 and over ; Apoptosis ; Bcl-2 protein ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; ErbB-2 protein ; Female ; Gene Expression Regulation, Neoplastic ; Gene set enrichment analysis ; Genes ; Genetic analysis ; Genetic factor ; Genetic factors ; Head & neck cancer ; Humanities and Social Sciences ; Humans ; Male ; Medical prognosis ; Middle Aged ; multidisciplinary ; Neoplasm Recurrence, Local - genetics ; Neoplasm Staging ; Nose ; Overall survival ; Paranasal Sinus Neoplasms - genetics ; Paranasal Sinus Neoplasms - mortality ; Paranasal Sinus Neoplasms - pathology ; Paranasal Sinus Neoplasms - surgery ; Patients ; Prognosis ; Prognosis analysis ; PTEN protein ; Recurrence-free survival ; Retrospective Studies ; Science ; Science (multidisciplinary) ; Sinus ; SNSCC ; Squamous cell carcinoma ; Surgery ; Tumors</subject><ispartof>Scientific reports, 2024-09, Vol.14 (1), p.22167-12, Article 22167</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c422t-844c4f276d37fcdbd507dec88472972671a01a57f35cfa39cac0406da8db55023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3110578437/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3110578437?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39333222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lian, Meng</creatorcontrib><creatorcontrib>Han, Boxuan</creatorcontrib><creatorcontrib>Chen, Jiaming</creatorcontrib><creatorcontrib>Shen, Xixi</creatorcontrib><creatorcontrib>Zhao, Yanming</creatorcontrib><creatorcontrib>Shi, Qian</creatorcontrib><creatorcontrib>Feng, Ling</creatorcontrib><creatorcontrib>He, Shizhi</creatorcontrib><creatorcontrib>Ma, Hongzhi</creatorcontrib><creatorcontrib>Hou, Lizhen</creatorcontrib><creatorcontrib>Zhong, Qi</creatorcontrib><creatorcontrib>Cao, Hongbao</creatorcontrib><creatorcontrib>Fang, Jugao</creatorcontrib><title>Investigating the impact of clinical and genetic factors on the post-surgery prognosis of sinonasal squamous cell carcinoma</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Sinonasal squamous cell carcinoma (SNSCC) is an aggressive cancer affecting the nasal and sinus regions, with its progression factors, particularly genetic ones, not yet fully understood. Here, we first conducted a retrospective study with 219 SNSCC patients to identify clinical factors affecting SNSCC prognosis. Additionally, we mined a vast literature dataset to uncover genetic factors associated with SNSCC progression. Based on this data, we constructed SNSCC prognosis pathways and performed a gene set enrichment analysis (GSEA). Clear operative margins were linked to a 73.5–86.3% improvement in overall survival and a 73.5–88.9% lower risk of recurrence. Nasal cavity-originated cases exhibited a 67.6–97.4% decrease in mortality and an 80.7–96.7% lower recurrence rate. Patients at T1-2 staging had a 65.0–80.6% reduced risk of death and recurrence compared to those at T3 stage. Additionally, we identified 53 genes associated with SNSCC, with 14 also implicated in primary tumor site, T stage, and operative margin. These genes, including EGFR, PIK3CA, ERBB2, PTEN, BCL2, BRAF, KRAS, and PRL, form a complex SNSCC-prognosis pathway and were significantly enriched in 42 KEGG pathways and Gene Ontology (GO) terms (FDR-corrected p-value < 0.001), influencing cell growth, apoptosis, and oncogenic signaling pathways. Our study suggests that three clinical parameters (operative margin type, primary tumor site, and T-stage) and 14 genetic factors may influence SNSCC prognosis post-surgery. These findings deepen our understanding of SNSCC and offer potential avenues to enhance its treatment and outcomes.</description><subject>631/67/1059</subject><subject>631/67/1536</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis</subject><subject>Bcl-2 protein</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>ErbB-2 protein</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene set enrichment analysis</subject><subject>Genes</subject><subject>Genetic analysis</subject><subject>Genetic factor</subject><subject>Genetic factors</subject><subject>Head & neck cancer</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Neoplasm Recurrence, Local - 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Here, we first conducted a retrospective study with 219 SNSCC patients to identify clinical factors affecting SNSCC prognosis. Additionally, we mined a vast literature dataset to uncover genetic factors associated with SNSCC progression. Based on this data, we constructed SNSCC prognosis pathways and performed a gene set enrichment analysis (GSEA). Clear operative margins were linked to a 73.5–86.3% improvement in overall survival and a 73.5–88.9% lower risk of recurrence. Nasal cavity-originated cases exhibited a 67.6–97.4% decrease in mortality and an 80.7–96.7% lower recurrence rate. Patients at T1-2 staging had a 65.0–80.6% reduced risk of death and recurrence compared to those at T3 stage. Additionally, we identified 53 genes associated with SNSCC, with 14 also implicated in primary tumor site, T stage, and operative margin. These genes, including EGFR, PIK3CA, ERBB2, PTEN, BCL2, BRAF, KRAS, and PRL, form a complex SNSCC-prognosis pathway and were significantly enriched in 42 KEGG pathways and Gene Ontology (GO) terms (FDR-corrected p-value < 0.001), influencing cell growth, apoptosis, and oncogenic signaling pathways. Our study suggests that three clinical parameters (operative margin type, primary tumor site, and T-stage) and 14 genetic factors may influence SNSCC prognosis post-surgery. These findings deepen our understanding of SNSCC and offer potential avenues to enhance its treatment and outcomes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>39333222</pmid><doi>10.1038/s41598-024-73157-6</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/67/1059 631/67/1536 Adult Aged Aged, 80 and over Apoptosis Bcl-2 protein Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery ErbB-2 protein Female Gene Expression Regulation, Neoplastic Gene set enrichment analysis Genes Genetic analysis Genetic factor Genetic factors Head & neck cancer Humanities and Social Sciences Humans Male Medical prognosis Middle Aged multidisciplinary Neoplasm Recurrence, Local - genetics Neoplasm Staging Nose Overall survival Paranasal Sinus Neoplasms - genetics Paranasal Sinus Neoplasms - mortality Paranasal Sinus Neoplasms - pathology Paranasal Sinus Neoplasms - surgery Patients Prognosis Prognosis analysis PTEN protein Recurrence-free survival Retrospective Studies Science Science (multidisciplinary) Sinus SNSCC Squamous cell carcinoma Surgery Tumors |
| title | Investigating the impact of clinical and genetic factors on the post-surgery prognosis of sinonasal squamous cell carcinoma |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T11%3A27%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Investigating%20the%20impact%20of%20clinical%20and%20genetic%20factors%20on%20the%20post-surgery%20prognosis%20of%20sinonasal%20squamous%20cell%20carcinoma&rft.jtitle=Scientific%20reports&rft.au=Lian,%20Meng&rft.date=2024-09-27&rft.volume=14&rft.issue=1&rft.spage=22167&rft.epage=12&rft.pages=22167-12&rft.artnum=22167&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-024-73157-6&rft_dat=%3Cproquest_doaj_%3E3110578437%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c422t-844c4f276d37fcdbd507dec88472972671a01a57f35cfa39cac0406da8db55023%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3110578437&rft_id=info:pmid/39333222&rfr_iscdi=true |