Adipocytes, Innate Immunity and Obesity: A Mini-Review

The role of adipose tissue (AT) inflammation in obesity and its multiple related-complications is a rapidly expanding area of scientific interest. Within the last 30 years, the role of the adipocyte as an endocrine and immunologic cell has been progressively established. Like the macrophage, the adi...

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Bibliographic Details
Published in:Frontiers in immunology 2021-06, Vol.12, p.650768-650768
Main Authors: Blaszczak, Alecia M, Jalilvand, Anahita, Hsueh, Willa A
Format: Article
Language:English
Subjects:
Adaptive Immunity - immunology
adipocytes
Adipocytes - cytology
Adipocytes - immunology
Adipocytes - metabolism
Adipokines - immunology
Adipokines - metabolism
adipose tissue
Adipose Tissue - cytology
Adipose Tissue - immunology
Adipose Tissue - metabolism
Cytokines - immunology
Cytokines - metabolism
Humans
Immunity, Innate - immunology
Immunology
inflammation
innate immunity
Macrophages - immunology
Macrophages - metabolism
obesity
Obesity - immunology
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
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Summary:The role of adipose tissue (AT) inflammation in obesity and its multiple related-complications is a rapidly expanding area of scientific interest. Within the last 30 years, the role of the adipocyte as an endocrine and immunologic cell has been progressively established. Like the macrophage, the adipocyte is capable of linking the innate and adaptive immune system through the secretion of adipokines and cytokines; exosome release of lipids, hormones, and microRNAs; and contact interaction with other immune cells. Key innate immune cells in AT include adipocytes, macrophages, neutrophils, and innate lymphoid cells type 2 (ILC2s). The role of the innate immune system in promoting adipose tissue inflammation in obesity will be highlighted in this review. T cells and B cells also play important roles in contributing to AT inflammation and are discussed in this series in the chapter on adaptive immunity.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.650768