Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus-Based Vaccines

Use of the vesicular stomatitis virus (VSV)-based Ebola virus vaccine during outbreaks and the potential use of a similar VSV-based Lassa virus vaccine has raised questions about the vaccines' stability should the cold chain fail. We demonstrated that current cold chain conditions might tolerat...

Full description

Saved in:
Bibliographic Details
Published in:Emerging infectious diseases 2019-08, Vol.25 (8), p.1563-1566
Main Authors: Stein, Derek R, Sroga, Patrycja, Warner, Bryce M, Deschambault, Yvon, Poliquin, Guillaume, Safronetz, David
Format: Article
Language:English
Subjects:
Animals
Clinical trials
Death
Disease Models, Animal
Disease Outbreaks
Dispatch
Ebola Vaccines - administration & dosage
Ebola Vaccines - genetics
Ebola Vaccines - immunology
Ebola virus
Ebolavirus - immunology
Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus–Based Vaccines
Female
Genetic Vectors - genetics
Guinea Pigs
Hemorrhagic Fever, Ebola - epidemiology
Hemorrhagic Fever, Ebola - mortality
Hemorrhagic Fever, Ebola - prevention & control
Hemorrhagic fevers
Humans
Immunization
Lassa fever
Lassa virus
Mortality
Stomatitis
Vaccination
Vaccine Potency
vaccine stability
Vaccines
Vesiculovirus - genetics
Viral hemorrhagic fever
viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Use of the vesicular stomatitis virus (VSV)-based Ebola virus vaccine during outbreaks and the potential use of a similar VSV-based Lassa virus vaccine has raised questions about the vaccines' stability should the cold chain fail. We demonstrated that current cold chain conditions might tolerate significant variances without affecting efficacy.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2508.190281