In situ formation of steroidal supramolecular gels designed for drug release

In this work, a steroidal gelator containing an imine bond was synthesized, and its gelation behavior as well as a sensitivity of its gels towards acids was investigated. It was shown that the gels were acid-responsive, and that the gelator molecules could be prepared either by a conventional synthe...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2013-03, Vol.18 (4), p.3745-3759
Main Authors: Bunzen, Hana, Kolehmainen, Erkki
Format: Article
Language:English
Subjects:
acid-responsive
Chloroquinolinols - chemistry
Cholesterol
Delayed-Action Preparations
Design
Drug Delivery Systems - methods
drug release
Gels - chemistry
Hydrogen-Ion Concentration
in situ gelation
Magnetic Resonance Spectroscopy
organogel
Solvents
Steroids
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Summary:In this work, a steroidal gelator containing an imine bond was synthesized, and its gelation behavior as well as a sensitivity of its gels towards acids was investigated. It was shown that the gels were acid-responsive, and that the gelator molecules could be prepared either by a conventional synthesis or directly in situ during the gel forming process. The gels prepared by both methods were studied and it was found that they had very similar macro- and microscopic properties. Furthermore, the possibility to use the gels as carriers for aromatic drugs such as 5-chloro-8-hydroxyquinoline, pyrazinecarboxamide, and antipyrine was investigated and the prepared two-component gels were studied with regard to their potential applications in drug delivery, particularly in a pH-controlled drug release.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules18043745