Myelin positron emission tomography (PET) imaging in multiple sclerosis

The first successful use of amyloid PET tracers specific for β-amyloid plaque detection in humans, was in 2004 (Klunk et al., 2004). [...]2011, white-matter uptake was considered as non-specific binding, when studies indicated special application to MS as a myelin marker (Stankoff et al., 2011). [.....

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Bibliographic Details
Published in:Neural regeneration research 2020-10, Vol.15 (10), p.1842-1843
Main Author: de Paula Faria, Daniele
Format: Article
Language:English
Subjects:
Brain research
Carbon
Central nervous system
Cognitive disorders
Dementia
Diagnosis
Diagnostic imaging
Disabilities
Disease
Diseases
Florbetapir
Flutemetamol
Inflammation
Magnetic resonance imaging
Medical examination
Medical schools
Methods
Multiple sclerosis
Myelin sheath
Nervous system
Patients
Peer review
Positron emission tomography
Radioisotopes
Tomography
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Summary:The first successful use of amyloid PET tracers specific for β-amyloid plaque detection in humans, was in 2004 (Klunk et al., 2004). [...]2011, white-matter uptake was considered as non-specific binding, when studies indicated special application to MS as a myelin marker (Stankoff et al., 2011). [...]higher efficiency in technique validation to arrive at proof-of-tool propriety becomes a prime necessity. In MS, although several animal models are available, none mimic the human disease completely. [...]choice of the appropriate model is based on research questions: is there progressive demyelination and remyelination; is the demyelinated area in the brain, focal or widespread; is there an inflammatory compound together with myelin changes; is the animal a model of relapsing-remitting (RRMS) or progressive (PMS) MS. [Figure 1] presents11C-PIB PET imaging in various species.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.280311