Preparation and characterization of poly (hydroxy butyrate)/chitosan blend scaffolds for tissue engineering applications

Poly (hydroxy butyrate) (PHB) is a biodegradable and biocompatible polymer with good mechanical properties. This polymer could be a promising material for scaffolds if some features improve. In the present work, new PHB/chitosan blend scaffolds were prepared as a three-dimensional substrate in carti...

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Bibliographic Details
Published in:Advanced biomedical research 2016, Vol.5 (1), p.177-177
Main Authors: Karbasi, Saeed, Khorasani, Saied Nouri, Ebrahimi, Somayeh, Khalili, Shahla, Fekrat, Farnoosh, Sadeghi, Davoud
Format: Article
Language:English
Subjects:
Acids
Adsorption
Biocompatibility
Blend
chitosan
Contact angle
Design of experiments
Mechanical properties
Molecular weight
Morphology
Original
poly (hydroxy butyrate)
Polymers
Porosity
salt leaching
scaffold
Scanning electron microscopy
Software
Solvents
Studies
Taguchi methods
Tissue engineering
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Summary:Poly (hydroxy butyrate) (PHB) is a biodegradable and biocompatible polymer with good mechanical properties. This polymer could be a promising material for scaffolds if some features improve. In the present work, new PHB/chitosan blend scaffolds were prepared as a three-dimensional substrate in cartilage tissue engineering. Chitosan in different weight percent was added to PHB and solved in trifluoroacetic acid. Statistical Taguchi method was employed in the design of experiments. The Fourier-transform infrared spectroscopy test revealed that the crystallization of PHB in these blends is suppressed with increasing the amount of chitosan. Scanning electron microscopy images showed a thin and rough top layer with a nodular structure, supported with a porous sub-layer in the surface of the scaffolds. degradation rate of the scaffolds was higher than pure PHB scaffolds. Maximum degradation rate has been seen for the scaffold with 90% wt. NaCl and 40% wt. chitosan. The obtained results suggest that these newly developed PHB/chitosan blend scaffolds may serve as a three-dimensional substrate in cartilage tissue engineering.
ISSN:2277-9175
2277-9175
DOI:10.4103/2277-9175.188490