Clinicopathologic features of 112 cases with mantle cell lymphoma

Objective： This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma （MCL）. Methods： Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization （FISH） detected a break in the CCND 1 gene. The t-tes...

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Bibliographic Details
Published in:Cancer biology & medicine 2015-03, Vol.12 (1), p.46-52
Main Authors: Zhou, Dong-Mei, Chen, Gang, Zheng, Xiong-Wei, Zhu, Wei-Feng, Chen, Bao-Zhen
Format: Article
Language:English
Subjects:
B细胞淋巴瘤
fluorescence in situ hybridization (FISH)
immunohistochemistry
Mantle cell lymphoma (MCL)
MCL
Original
prognosis
临床
免疫组化法
病理特征
细胞周期蛋白D1
统计分析
荧光原位杂交
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Summary:Objective： This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma （MCL）. Methods： Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization （FISH） detected a break in the CCND 1 gene. The t-test was used in the statistical analysis. Results： All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CDS-MCL. IgH/CCND 1 polyploid was observed in 2 classic cases. Conclusion： MCL is a type of special immunophenotypic B-cell lymphoma, The prognoses ofblastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.
ISSN:2095-3941
2095-3941
DOI:10.7497/j.issn.2095-3941.2015.0007