Crosstalk between protein post-translational modifications and phase separation

The phenomenon of phase separation is quite common in cells, and it is involved in multiple processes of life activities. However, the current research on the correlation between protein modifications and phase separation and the interference with the tendency of phase separation has some limitation...

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Bibliographic Details
Published in:Cell communication and signaling 2024-02, Vol.22 (1), p.110-110, Article 110
Main Authors: Liu, Yang, Feng, Wenjuan, Wang, Yunshan, Wu, Bin
Format: Article
Language:English
Subjects:
Acetylation
Amino acids
Biomolecular condensates
Coronaviruses
Cyclin-dependent kinases
DNA damage
DNA repair
Entropy
Environmental stress
Gene regulation
Homeostasis
Kinases
Neurodegenerative Diseases
Phase Separation
Phosphatase
Phosphorylation
Physiology
Polyethylene glycol
Post-translation
Post-translational modifications
Protein Processing, Post-Translational
Proteins
Review
RNA polymerase
Signal transduction
SUMO protein
Translation
Tumors
Ubiquitination
Viral Infections
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Summary:The phenomenon of phase separation is quite common in cells, and it is involved in multiple processes of life activities. However, the current research on the correlation between protein modifications and phase separation and the interference with the tendency of phase separation has some limitations. Here we focus on several post-translational modifications of proteins, including protein phosphorylation modification at multiple sites, methylation modification, acetylation modification, ubiquitination modification, SUMOylation modification, etc., which regulate the formation of phase separation and the stability of phase separation structure through multivalent interactions. This regulatory role is closely related to the development of neurodegenerative diseases, tumors, viral infections, and other diseases, and also plays essential functions in environmental stress, DNA damage repair, transcriptional regulation, signal transduction, and cell homeostasis of living organisms, which provides an idea to explore the interaction between novel protein post-translational modifications and phase separation. Video Abstract.
ISSN:1478-811X
1478-811X
DOI:10.1186/s12964-023-01380-1