Cardiorespiratory optimal point during exercise testing as a predictor of all-cause mortality

The cardiorespiratory optimal point (COP) is a novel index, calculated as the minimum oxygen ventilatory equivalent (VE/VO2) obtained during cardiopulmonary exercise testing (CPET). In this study we demonstrate the prognostic value of COP both independently and in combination with maximum oxygen con...

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Bibliographic Details
Published in:Revista portuguesa de cardiologia 2017-04, Vol.36 (4), p.261-269
Main Authors: Ramos, Plínio S., Araújo, Claudio Gil S.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cardiopulmonary exercise testing
Cause of Death
Consumo de oxigênio
Exercise
Exercise Test
Exercício
Female
Humans
Male
Middle Aged
Oxygen Consumption
Oxygen uptake
Predictive Value of Tests
Prognosis
Retrospective Studies
Teste cardiopulmonar de exercício
Ventilation
Ventilação
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Description
Summary:The cardiorespiratory optimal point (COP) is a novel index, calculated as the minimum oxygen ventilatory equivalent (VE/VO2) obtained during cardiopulmonary exercise testing (CPET). In this study we demonstrate the prognostic value of COP both independently and in combination with maximum oxygen consumption (VO2max) in community-dwelling adults. Maximal cycle ergometer CPET was performed in 3331 adults (66% men) aged 40-85 years, healthy (18%) or with chronic disease (81%). COP cut-off values of 30 were selected based on the log-rank test. Risk discrimination was assessed using COP as an independent predictor and combined with VO2max. Median follow-up was 6.4 years (7.1% mortality). Subjects with COP >30 demonstrated increased mortality compared to those with COP
ISSN:0870-2551
2174-2030
DOI:10.1016/j.repc.2016.09.017