Primary ciliated muconodular papillary tumor: A rare pulmonary disease and literature review of 65 cases

A ciliated muconodular papillary tumor (CMPT) or bronchiolar adenoma (BA) is a rather rare and unique type of lung tumor characterized by tripartite cellular components with a papillary‐predominant structure including ciliated columnar cells, mucinous cells, and basal cells. Here, we present the cas...

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Bibliographic Details
Published in:Thoracic cancer 2021-06, Vol.12 (12), p.1917-1922
Main Authors: Wang, Yanye, Wang, Dan, Wang, Jun, Zhao, Shikang, Ren, Dian, Chen, Gang, Wang, Qiuhui, Xu, Dongbo, Xu, Song
Format: Article
Language:English
Subjects:
Antigens
bronchiolar adenoma (BA)
Carcinoma, Papillary - diagnosis
Case Report
Case Reports
ciliated muconodular papillary tumor (CMPT)
Female
Genes
Humans
Literature reviews
Lung cancer
Lung Neoplasms - diagnosis
Lymphatic system
Metastasis
Middle Aged
Mutation
PD‐L1
Pulmonary arteries
sequencing
surgery
Tumors
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Summary:A ciliated muconodular papillary tumor (CMPT) or bronchiolar adenoma (BA) is a rather rare and unique type of lung tumor characterized by tripartite cellular components with a papillary‐predominant structure including ciliated columnar cells, mucinous cells, and basal cells. Here, we present the case of a 64‐year‐old woman who was diagnosed with CMPT in our center. In addition to reporting the clinicopathological characteristics of this case, we also conducted whole exome sequencing (WES) to explore the underlying mechanism. According to current evidence, CMPTs tends to be benign or of low grade malignancy. However, this requires further validation. A ciliated muconodular papillary tumor (CMPT)/bronchiolar adenoma (BA) is a rare and rather unique type of lung tumor characterized by tripartite cellular components with a papillary‐predominant structure including ciliated columnar cells, mucinous cells, and basal cells. We present the case of a 64‐year‐old woman who was diagnosed with CMPT in our center. In addition to reporting the clinicopathological characteristics of this case, we also conducted whole exome sequencing (WES) to explore the underlying mechanism. According to the current evidence, CMPTs tends to be benign or of low grade malignancy. However, this requires further validation.
ISSN:1759-7706
1759-7714
DOI:10.1111/1759-7714.13963