Transcriptome analysis and connectivity mapping of Cissampelos pareira L. provides molecular links of ESR1 modulation to viral inhibition

Bioactive fractions obtained from medicinal plants which have been used for the treatment of multiple diseases could exert their effects by targeting common pathways. Prior knowledge of their usage could allow us to identify novel molecular links. In this study, we explored the molecular basis of ac...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2021-10, Vol.11 (1), p.20095-20095, Article 20095
Main Authors: Haider, Madiha, Dholakia, Dhwani, Panwar, Aleksha, Garg, Parth, Gheware, Atish, Singh, Dayanidhi, Singhal, Khushboo, Burse, Shaunak A., Kumari, Surekha, Sharma, Anmol, Ray, Arjun, Medigeshi, Guruprasad R., Sharma, Upendra, Prasher, Bhavana, Mukerji, Mitali
Format: Article
Language:English
Subjects:
631/154
631/61/212
Antiviral activity
Antiviral Agents - pharmacology
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - virology
Cell lines
Cissampelos - chemistry
Cissampelos pareira
Dengue - drug therapy
Dengue - metabolism
Dengue - pathology
Dengue - virology
Dengue fever
Dengue Virus
Emetine
Estrogen Receptor alpha - genetics
Estrogen Receptor alpha - metabolism
Estrogen receptors
Estrogens
Female
Fever
Humanities and Social Sciences
Humans
MCF-7 Cells
Medicinal plants
multidisciplinary
Plant Extracts - pharmacology
Science
Science (multidisciplinary)
Transcriptome - drug effects
Transcriptomes
Vector-borne diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bioactive fractions obtained from medicinal plants which have been used for the treatment of multiple diseases could exert their effects by targeting common pathways. Prior knowledge of their usage could allow us to identify novel molecular links. In this study, we explored the molecular basis of action of one such herbal formulation Cissampelos pareira L. (Cipa), used for the treatment of female hormone disorders and fever. Transcriptomic studies on MCF7 cell lines treated with Cipa extract carried out using Affymetrix arrays revealed a downregulation of signatures of estrogen response potentially modulated through estrogen receptor α (ERα). Molecular docking analysis identified 38 Cipa constituents that potentially bind (ΔG 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-99444-0