Quantitative Chemical Composition, Anti-Oxidant Activity, and Inhibition of TNF Release by THP-1 Cells Induced by Extracts of Echinodorus macrophyllus and Echinodorus grandiflorus

This study investigated the similarities between and , plant species that are traditionally used in Brazil to treat rheumatism and arthritis, whose anti-inflammatory effects are supported by scientific evidence. The contents of - and -aconitic acid, homoorientin, chicoric acid, swertisin, caffeoyl-f...

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Published in:Antioxidants 2023-06, Vol.12 (7), p.1365
Main Authors: Rocha, Marina Pereira, da Silva, Lyandra Maciel Cabral, Silva, Laura Paulino Maia, Gomes, José Hugo de Sousa, Pádua, Rodrigo Maia de, Batista, João Aguiar Nogueira, Sena, Marcelo Martins, Campana, Priscilla Rodrigues Valadares, Braga, Fernão Castro
Format: Article
Language:English
Subjects:
Acids
Aconitic acid
anti-oxidant activity
Antioxidants
Arthritis
Biological activity
Biomarkers
Chemical composition
chemical markers
Chromatography
Echinodorus grandiflorus
Echinodorus macrophyllus
Ethanol
Flavonoids
Inflammation
inhibition of TNF release
Leaves
molecular analysis
Morphology
Oxidants
Phylogenetics
Principal components analysis
Tartaric acid
Tumor necrosis factor-TNF
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Summary:This study investigated the similarities between and , plant species that are traditionally used in Brazil to treat rheumatism and arthritis, whose anti-inflammatory effects are supported by scientific evidence. The contents of - and -aconitic acid, homoorientin, chicoric acid, swertisin, caffeoyl-feruloyl-tartaric acid, and di-feruloyl-tartaric acid were quantified by UPLC-DAD in various hydroethanolic extracts from the leaves, whereas their anti-oxidant activity and their effect on TNF release by LPS-stimulated THP-1 cells were assessed to evaluate potential anti-inflammatory effects. The 50% and 70% ethanol extracts showed higher concentrations of the analyzed markers in two commercial samples and a cultivated specimen of , as well as in a commercial lot of . However, distinguishing between the species based on marker concentrations was not feasible. The 50% and 70% ethanol extracts also exhibited higher biological activity, yet they did not allow differentiation between the species, indicating similar chemical composition and biological effects. Principal component analysis highlighted comparable chemical composition and biological activity among the commercial samples of , while successfully distinguishing the cultivated specimen from the commercial lots. In summary, no differences were observed between the two species in terms of the evaluated chemical markers and biological activities.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox12071365