Basolateral amygdala oscillations enable fear learning in a biophysical model

The basolateral amygdala (BLA) is a key site where fear learning takes place through synaptic plasticity. Rodent research shows prominent low theta (~3-6 Hz), high theta (~6-12 Hz), and gamma (>30 Hz) rhythms in the BLA local field potential recordings. However, it is not understood what role the...

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Published in:eLife 2024-11, Vol.12
Main Authors: Cattani, Anna, Arnold, Don B, McCarthy, Michelle, Kopell, Nancy
Format: Article
Language:English
Subjects:
Amygdala
Analysis
Animals
Associative learning
Basolateral Nuclear Complex - physiology
Biophysics
BLA interneurons
Computational and Systems Biology
Electrophysiological recording
Fear - physiology
Fear conditioning
Firing pattern
gamma rhythms
Interneurons
Interneurons - physiology
Laboratory animals
Learning - physiology
Models, Neurological
Neuronal Plasticity - physiology
Neurons
Neuroscience
Potassium
Rhythm
Rodents
SOM
Synapses
Synaptic plasticity
theta
Theta Rhythm - physiology
Theta rhythms
VIP
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Arnold, Don B
McCarthy, Michelle
Kopell, Nancy
description The basolateral amygdala (BLA) is a key site where fear learning takes place through synaptic plasticity. Rodent research shows prominent low theta (~3-6 Hz), high theta (~6-12 Hz), and gamma (>30 Hz) rhythms in the BLA local field potential recordings. However, it is not understood what role these rhythms play in supporting the plasticity. Here, we create a biophysically detailed model of the BLA circuit to show that several classes of interneurons (PV, SOM, and VIP) in the BLA can be critically involved in producing the rhythms; these rhythms promote the formation of a dedicated fear circuit shaped through spike-timing-dependent plasticity. Each class of interneurons is necessary for the plasticity. We find that the low theta rhythm is a biomarker of successful fear conditioning. The model makes use of interneurons commonly found in the cortex and, hence, may apply to a wide variety of associative learning situations.
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source Publicly Available Content (ProQuest); PubMed Central
subjects Amygdala
Analysis
Animals
Associative learning
Basolateral Nuclear Complex - physiology
Biophysics
BLA interneurons
Computational and Systems Biology
Electrophysiological recording
Fear - physiology
Fear conditioning
Firing pattern
gamma rhythms
Interneurons
Interneurons - physiology
Laboratory animals
Learning - physiology
Models, Neurological
Neuronal Plasticity - physiology
Neurons
Neuroscience
Potassium
Rhythm
Rodents
SOM
Synapses
Synaptic plasticity
theta
Theta Rhythm - physiology
Theta rhythms
VIP
title Basolateral amygdala oscillations enable fear learning in a biophysical model
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