Seroprevalence of Anti-SARS-CoV-2 IgG Antibodies among HIV Infected Individuals Attending ART Centre at Pune: A Cross-Sectional Study

• Published in: Journal of the International Association of Providers of AIDS Care 2022-01, Vol.21, p.23259582221077943-23259582221077943
• Main Authors: Ghate, Manisha, Shidhaye, Pallavi, Gurav, Shraddha, Gadhe, Keshav, Kale, Varsha, Jain, Preeti, Thakar, Madhuri
• Format: Article
• Language: English
• Subjects: Antibodies; Antiretroviral drugs; COVID-19; COVID-19 and the Continuum of HIV Care and Prevention- Original; Cross-Sectional Studies; Female; HIV; HIV Infections - drug therapy; HIV Infections - epidemiology; Human immunodeficiency virus; Humans; Immunoglobulin G; India - epidemiology; SARS-CoV-2; Seroepidemiologic Studies; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2
• ISSN: 2325-9582; 2325-9574; 2325-9582
• DOI: 10.1177/23259582221077943

Background: We aimed to determine the anti-SARS-CoV-2 IgG antibodies among people living with HIV (PLHIV) in Pune, India. Methods: This cross-sectional study was conducted between March 2021 and June 2021. Demographic and clinical information related to coronavirus disease 2019 (COVID-19) were recorded on structured questionnaires. Blood samples were collected and tested for anti-SARS-CoV-2 IgG antibodies using commercial ELISA. Results: Of the 405 HIV infected individuals enrolled in the study, 223(55.1%) were females. Mean age and CD4 count of participants were 42 years (SD: 10) and 626 cells/mm3 (SD: 284) respectively. A total of 382 (95%) PLHIV were virologically suppressed. The seropositivity against SARS-CoV-2 was found in 221 PLHIV (54.6%, 95% CI: 49.7-59.4). No significant association was found between demographic or clinical factors and seropositivity. Conclusion: A high prevalence of anti-SARS-CoV-2 IgG antibodies was found among PLHIV attending ART centre indicating an exposure to the virus among them.