Electrophysiological effects of adipose graft transposition procedure (AGTP) on the post-myocardial infarction scar: A multimodal characterization of arrhythmogenic substrate

ObjectiveTo assess the arrhythmic safety profile of the adipose graft transposition procedure (AGTP) and its electrophysiological effects on post-myocardial infarction (MI) scar. BackgroundMyocardial repair is a promising treatment for patients with MI. The AGTP is a cardiac reparative therapy that...

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Published in:Frontiers in cardiovascular medicine 2022-09, Vol.9, p.983001-983001
Main Authors: Adeliño, Raquel, Martínez-Falguera, Daina, Curiel, Carolina, Teis, Albert, Marsal, Roger, Rodríguez-Leor, Oriol, Prat-Vidal, Cristina, Fadeuilhe, Edgar, Aranyó, Júlia, Revuelta-López, Elena, Sarrias, Axel, Bazan, Víctor, Andrés-Cordón, Joan F., Roura, Santiago, Villuendas, Roger, Lupón, Josep, Bayes-Genis, Antoni, Gálvez-Montón, Carolina, Bisbal, Felipe
Format: Article
Language:English
Subjects:
adipose graft transposition procedure
arrhythmic risk
Cardiovascular Medicine
mapping
myocardial infarction
myocardial repair
ventricular tachycardia
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Summary:ObjectiveTo assess the arrhythmic safety profile of the adipose graft transposition procedure (AGTP) and its electrophysiological effects on post-myocardial infarction (MI) scar. BackgroundMyocardial repair is a promising treatment for patients with MI. The AGTP is a cardiac reparative therapy that reduces infarct size and improves cardiac function. The impact of AGTP on arrhythmogenesis has not been addressed. MethodsMI was induced in 20 swine. Contrast-enhanced magnetic resonance (ce-MRI), electrophysiological study (EPS), and left-ventricular endocardial high-density mapping were performed 15 days post-MI. Animals were randomized 1:1 to AGTP or sham-surgery group and monitored with ECG-Holter. Repeat EPS, endocardial mapping, and ce-MRI were performed 30 days post-intervention. Myocardial SERCA2, Connexin-43 (Cx43), Ryanodine receptor-2 (RyR2), and cardiac troponin-I (cTnI) gene and protein expression were evaluated. ResultsThe AGTP group showed a significant reduction of the total infarct scar, border zone and dense scar mass by ce-MRI (p = 0.04), and a decreased total scar and border zone area in bipolar voltage mapping (p < 0.001). AGTP treatment significantly reduced the area of very-slow conduction velocity (
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2022.983001