Virological Mechanisms in the Coinfection between HIV and HCV

Due to shared transmission routes, coinfection with Hepatitis C Virus (HCV) is common in patients infected by Human Immunodeficiency Virus (HIV). The immune-pathogenesis of liver disease in HIV/HCV coinfected patients is a multifactorial process. Several studies demonstrated that HIV worsens the cou...

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Bibliographic Details
Published in:Mediators of Inflammation 2015-01, Vol.2015 (2015), p.285-291-125
Main Authors: Focà, Alfredo, Marascio, Nadia, Quirino, Angela, Pavia, Grazia, Zicca, Emilia, Liberto, Maria Carla, Torti, Carlo
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - therapeutic use
Coinfection - virology
Comorbidity
Health aspects
Hepacivirus
Hepatitis
Hepatitis C - complications
Hepatitis C - virology
Hepatitis C virus
HIV
HIV (Viruses)
HIV Infections - complications
HIV Infections - virology
Human immunodeficiency virus
Humans
Immune System
Inflammation - pathology
Inflammation - virology
Interferon
Kinases
Liver Cirrhosis - pathology
Liver Cirrhosis - virology
Medical research
Medicine, Experimental
Physiological aspects
Review
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Summary:Due to shared transmission routes, coinfection with Hepatitis C Virus (HCV) is common in patients infected by Human Immunodeficiency Virus (HIV). The immune-pathogenesis of liver disease in HIV/HCV coinfected patients is a multifactorial process. Several studies demonstrated that HIV worsens the course of HCV infection, increasing the risk of cirrhosis and hepatocellular carcinoma. Also, HCV might increase immunological defects due to HIV and risk of comorbidities. A specific cross-talk among HIV and HCV proteins in coinfected patients modulates the natural history, the immune responses, and the life cycle of both viruses. These effects are mediated by immune mechanisms and by a cross-talk between the two viruses which could interfere with host defense mechanisms. In this review, we focus on some virological/immunological mechanisms of the pathogenetic interactions between HIV and HCV in the human host.
ISSN:0962-9351
1466-1861
DOI:10.1155/2015/320532