TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial

[Display omitted] •TBG-136, a Schizophyllum commune-derived β-glucan significantly increased lactobacillus bacterial population in the gut.•Supplementation of TBG-136 significantly improved the rectosigmoid colon transit time (CTT) and the number of defecations.•One of the earliest clinical trials i...

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Published in:Journal of functional foods 2023-08, Vol.107, p.105668, Article 105668
Main Authors: Jang, Hui-Yeon, Jung, Su-Jin, Park, Eun-Ock, Kim, Soo-Dong, Kim, Je-Kyoung, Chae, Soo-Wan, Cha, Youn–Soo, Lee, Seung-Ok
Format: Article
Language:English
Subjects:
clinical trials
Constipation
Gut bacteria
immunomodulation
Intestinal health
intestinal microorganisms
intestines
Lactobacillus
placebos
quality of life
Schizophyllum commune
β-glucan
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Summary:[Display omitted] •TBG-136, a Schizophyllum commune-derived β-glucan significantly increased lactobacillus bacterial population in the gut.•Supplementation of TBG-136 significantly improved the rectosigmoid colon transit time (CTT) and the number of defecations.•One of the earliest clinical trials involving Schizophyllum commune-derived β-glucan.•Study demonstrates the positive influence of TBG-136 on bowel movement, constipation-related symptoms, and quality of life in patients with functional constipation. β-glucan exerts beneficial biological activities such as immunoregulatory, anticancer, antioxidative, antiaging, and wound healing. However, the effects of β-glucan on constipation have not been thoroughly studied. Thus, the present study aimed to investigate the effects of β-glucan-derived from Schizophyllum commune supplementation (TBG-136) on gut microbiota and intestinal health in constipated subjects. As a result, Lactobacillus was significantly increased in the TBG-136 group compared to the placebo group (P 
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2023.105668