Medulloblastoma: evaluation of proliferative index by monoclonal antibody Mib-1, its prognostic correlation and therapeutic implications

In the past few years, the monoclonal antibody MIB-1 has been used by researchers in order to retrospectively study paraffin imbibed tumor fragments. The medulloblastoma is the most common malignant central nervous system tumor in childhood. The objectives were: determination of the mean Mib-1 LI va...

Full description

Saved in:
Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2003-09, Vol.61 (3A), p.547-551
Main Authors: Ferrari, Antonio Fernandes, Araújo, Maria Betânia Mahler, Aguiar, Paulo Henrique, Plese, José Pindaro Pereira
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies, Antinuclear - analysis
Antibodies, Monoclonal - analysis
Biomarkers, Tumor - analysis
Cerebellar Neoplasms - mortality
Cerebellar Neoplasms - pathology
Cerebellar Neoplasms - therapy
Child
Child, Preschool
Female
Humans
Immunohistochemistry
Ki-67 Antigen - immunology
labelling index (LI)
Male
medulloblastoma
Medulloblastoma - mortality
Medulloblastoma - pathology
Medulloblastoma - therapy
mib-1
Neoplasm Staging
NEUROSCIENCES
Prognosis
prognostic factors
PSYCHIATRY
Retrospective Studies
Survival Analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the past few years, the monoclonal antibody MIB-1 has been used by researchers in order to retrospectively study paraffin imbibed tumor fragments. The medulloblastoma is the most common malignant central nervous system tumor in childhood. The objectives were: determination of the mean Mib-1 LI value from these patients, as well as the prognostic value of the method. This retrospective study represents an analysis of the cellular proliferation index of posterior fossa medulloblastomas collected from 22 patients at A.C. Camargo Hospital, from January 1990 to December 1999. The histopathological diagnosis was confirmed by H&E and proliferative index (LI) was achived with Mib-1 which detects proliferating cells during G1, G2, S and M phases. The results demostrated that the mean Mib-1 was 30,1%, and ranged from 5,2% to 62,0%.In conclusion, this method has prognostic value, has to be used as routine for patients harboring medulloblastomas and the ones who have PI greater than the mean value found in this study, should be treated aggressively.
ISSN:0004-282X
1678-4227
0004-282X
1678-4227
DOI:10.1590/S0004-282X2003000400004